Serum-based DNA methylation biomarkers in colorectal cancer: potential for screening and early detection.
Serum-based DNA methylation biomarkers in colorectal cancer: potential for screening and early detection.
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DOI：
10.7150/jca.5839
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发表时间：
2013
影响因子：
3.9
通讯作者：
Stojadinovic A
中科院分区：
文献类型：
--
作者：
Summers T;Langan RC;Nissan A;Brücher BL;Bilchik AJ;Protic M;Daumer M;Avital I;Stojadinovic A
结直肠癌(CRC)是美国癌症相关死亡的第三大常见原因。早期识别和治疗癌前病变或结节阴性结直肠癌是非常有效的干预措施，可以显著降低特定疾病的死亡率。结肠镜检查仍然是一种高效的主要筛查工具，因为它具有出色的诊断准确性，并且能够去除癌前病变。然而，该程序的性质限制了用于基于人群的结直肠癌筛查的结肠镜检查的依从性。基于血液的生物标记物可以实现在这些患者的筛查和护理方面的重大进步，它可以准确地识别那些可能受益于早期和/或更频繁的疾病监测的结直肠癌高危患者。我们回顾并在此讨论了基于血清DNA甲基化的生物标志物用于结直肠癌筛查和早期检测的可能性。
Colorectal cancer (CRC) is the third most common cause of cancer-related death in the United States. Early identification and treatment of pre-cancerous colorectal lesions, or node-negative CRC are highly effective interventions that substantially reduce disease-specific mortality. Colonoscopy remains a highly effective primary screening tool based on its excellent diagnostic accuracy, and its ability to remove pre-cancerous lesions. However, the nature of the procedure limits compliance with colonoscopy intended for population-based CRC screening. A significant advance in the screening and care of these patients could be realized by blood-based biomarkers, which could accurately identify patients at-risk for CRC development whom might benefit from early and/or more frequent surveillance for disease. We reviewed and herein discuss the potential for serum based DNA methylation biomarkers for screening and early detection of CRC.
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影响因子：
10.3
作者：
Glass, Andrew G.;Lacey, James V., Jr.;Hoover, Robert N.
通讯作者：
Hoover, Robert N.
影响因子：
6.2
作者：
Liggett, Thomas;Melnikov, Anatoliy;Levenson, Victor
通讯作者：
Levenson, Victor
影响因子：
--
作者：
Goebel G;Zitt M;Zitt M;Müller HM
通讯作者：
Müller HM
影响因子：
4.7
作者：
Liggett TE;Melnikov A;Yi Q;Replogle C;Hu W;Rotmensch J;Kamat A;Sood AK;Levenson V
通讯作者：
Levenson V
影响因子：
3.7
作者：
Tóth K;Sipos F;Kalmár A;Patai AV;Wichmann B;Stoehr R;Golcher H;Schellerer V;Tulassay Z;Molnár B
通讯作者：
Molnár B