Opposed Behavioural Outputs of Increased Dopamine Transmission in Prefrontocortical and Subcortical Areas: A Role for the Cortical D‐1 Dopamine Receptor
Opposed Behavioural Outputs of Increased Dopamine Transmission in Prefrontocortical and Subcortical Areas: A Role for the Cortical D‐1 Dopamine Receptor
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前额皮质和皮质下区域多巴胺传递增加的相反行为输出：皮质 D-1 多巴胺受体的作用
DOI：
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发表时间：
1991
影响因子：
3.4
通讯作者：
J. Tassin
中科院分区：
文献类型：
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作者：
Paul Vezina;G. Blanc;Jacques Glowinski;J. Tassin
多项研究表明，支配内侧前额皮质（mPFC）的多巴胺能神经元可能抑制运动行为。然而，证据仍然是间接的，因为测试的操作专门旨在永久消耗 mPFC 多巴胺。在这里，我们在大鼠中证明，通过局部注射安非他明，该部位的多巴胺传输急剧增加，抑制了安非他明在伏隔核（N.Acc）中已知的运动激活作用。此外，mPFC 内注射 D-1 多巴胺受体拮抗剂 SCH-23390，而不是其他对去甲肾上腺素能、5-羟色胺能和 D-2 多巴胺受体具有更大亲和力的多巴胺拮抗剂，增强了 N.Acc 内诱导的运动。安非他明。这些发现为 mPFC 多巴胺抑制运动活动提供了直接证据，并表明它作用于该位点的 D-1 多巴胺受体。
The possibility that the dopaminergic neurons innervating the medial prefrontal cortex (mPFC) can inhibit locomotor behaviour has been suggested in several studies. The evidence remains indirect, however, because the manipulations tested aimed exclusively at permanently depleting mPFC dopamine. Here we demonstrate in rats that acute increases in dopamine transmission in this site by local injections of amphetamine inhibit the known locomotor‐activating effects of amphetamine in the nucleus accumbens (N.Acc). Further, intra‐mPFC injections of the D‐1 dopamine receptor antagonist SCH‐23390, but not other dopamine antagonists with greater affinities for noradrenergic, serotonergic and D‐2 dopamine receptors, enhanced the locomotion induced by intra‐N.Acc. amphetamine. These findings provide direct evidence for the inhibition of locomotor activity by mPFC dopamine and suggest that it is acting at D‐1 dopamine receptors in this site.
DOI：
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发表时间：
1989-03
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
S. Sesack;B. Bunney
通讯作者：
S. Sesack;B. Bunney
DOI：
10.1073/pnas.86.22.9015
发表时间：
1989-11-01
影响因子：
11.1
作者：
GOLDMANRAKIC, PS;LERANTH, C;GEFFARD, M
通讯作者：
GEFFARD, M