Lung cancer and socioeconomic status in a pooled analysis of case-control studies.
Lung cancer and socioeconomic status in a pooled analysis of case-control studies.
复制标题
DOI：
10.1371/journal.pone.0192999
复制
发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Behrens T
中科院分区：
文献类型：
--
作者：
Hovanec J;Siemiatycki J;Conway DI;Olsson A;Stücker I;Guida F;Jöckel KH;Pohlabeln H;Ahrens W;Brüske I;Wichmann HE;Gustavsson P;Consonni D;Merletti F;Richiardi L;Simonato L;Fortes C;Parent ME;McLaughlin J;Demers P;Landi MT;Caporaso N;Tardón A;Zaridze D;Szeszenia-Dabrowska N;Rudnai P;Lissowska J;Fabianova E;Field J;Dumitru RS;Bencko V;Foretova L;Janout V;Kromhout H;Vermeulen R;Boffetta P;Straif K;Schüz J;Kendzia B;Pesch B;Brüning T;Behrens T
在一些研究中已经观察到低社会经济地位（SES）与肺癌之间的关联，但通常没有对吸烟行为进行充分的控制。我们研究了肺癌和职业性SES之间的关系，使用来自国际汇总SYNERGY研究的数据。来自欧洲和加拿大的12项病例对照研究被纳入分析。基于研究参与者的职业史，我们使用国际社会经济职业地位指数（ISEI）和欧洲社会经济分类（ESeC）测量SES。我们使用不同的标准将ISEI范围划分为不同的类别。按性别分层，我们通过非条件logistic回归计算优势比（OR）和95%置信区间（CI），调整年龄，学习和吸烟行为。我们对肺癌的组织学亚型进行了分析，并对研究区域、出生队列、教育和已知肺癌致癌物的职业暴露进行了亚组分析。分析数据集包括17，021例病例和20，885例对照。肺癌和低SES之间有一个很强的升高的OR，在调整吸烟后大大减弱，但是社会梯度仍然存在。SES在肺癌风险方面的差异在男性中更高（最低与最高SES类别：ISEI OR 1.84（95% CI 1.61-2.09）; ESec OR 1.53（95% CI 1.44-1.63）），高于女性（最低与最高SES类别：ISEI OR 1.54（95% CI 1.20-1.98）; ESec OR 1.34（95% CI 1.19-1.52））。在调整吸烟行为后，SES仍然是肺癌的危险因素。
An association between low socioeconomic status (SES) and lung cancer has been observed in several studies, but often without adequate control for smoking behavior. We studied the association between lung cancer and occupationally derived SES, using data from the international pooled SYNERGY study. Twelve case-control studies from Europe and Canada were included in the analysis. Based on occupational histories of study participants we measured SES using the International Socio-Economic Index of Occupational Status (ISEI) and the European Socio-economic Classification (ESeC). We divided the ISEI range into categories, using various criteria. Stratifying by gender, we calculated odds ratios (OR) and 95% confidence intervals (CI) by unconditional logistic regression, adjusting for age, study, and smoking behavior. We conducted analyses by histological subtypes of lung cancer and subgroup analyses by study region, birth cohort, education and occupational exposure to known lung carcinogens. The analysis dataset included 17,021 cases and 20,885 controls. There was a strong elevated OR between lung cancer and low SES, which was attenuated substantially after adjustment for smoking, however a social gradient persisted. SES differences in lung cancer risk were higher among men (lowest vs. highest SES category: ISEI OR 1.84 (95% CI 1.61–2.09); ESeC OR 1.53 (95% CI 1.44–1.63)), than among women (lowest vs. highest SES category: ISEI OR 1.54 (95% CI 1.20–1.98); ESeC OR 1.34 (95% CI 1.19–1.52)). SES remained a risk factor for lung cancer after adjustment for smoking behavior.
登录
查看更多内容
影响因子：
5.4
作者：
Hystad, Perry;Carpiano, Richard M.;Brauer, Michael
通讯作者：
Brauer, Michael
DOI：
10.1097/jom.0b013e318188b90a
发表时间：
2008-12-01
影响因子：
3.2
作者：
Arheart, Kristopher L.;Lee, David J.;Erard, Michael J.
通讯作者：
Erard, Michael J.
影响因子：
7.2
作者：
Conway, David I.;McMahon, Alex D.;McKinney, Patricia A.
通讯作者：
McKinney, Patricia A.
影响因子：
7.7
作者：
Hart, CL;Hole, DJ;Hawthorne, VM
通讯作者：
Hawthorne, VM
影响因子：
2.3
作者：
Clegg, Limin X.;Reichman, Marsha E.;Miller, Barry A.;Hankey, Benjamin F.;Singh, Gopal K.;Lin, Yi Dan;Goodman, Marc T.;Lynch, Charles F.;Schwartz, Stephen M.;Chen, Vivien W.;Bernstein, Leslie;Gomez, Scarlett L.;Graff, John J.;Lin, Charles C.;Johnson, Norman J.;Edwards, Brenda K.
通讯作者：
Edwards, Brenda K.