Variation in Arabidopsis flowering time associated with cis-regulatory variation in CONSTANS.
Variation in Arabidopsis flowering time associated with cis-regulatory variation in CONSTANS.
复制标题
DOI：
10.1038/ncomms4651
复制
发表时间：
2014-04-16
影响因子：
16.6
通讯作者：
Purugganan, Michael D.
中科院分区：
文献类型：
--
作者：
Rosas, Ulises;Mei, Yu;Xie, Qiguang;Banta, Joshua A.;Zhou, Royce W.;Seufferheld, Gabriela;Gerard, Silvia;Chou, Lucy;Bhambhra, Naeha;Parks, Jennifer Deane;Flowers, Jonathan M.;McClung, C. Robertson;Hanzawa, Yoshie;Purugganan, Michael D.
开花的开始，即从营养发育到生殖发育的转变，是显花植物生活史上的一个重要转变。最近的工作表明，顺式调控突变中的突变应该在这种（以及其他）重要适应性性状的进化中发挥关键作用，但迄今为止，几乎没有证据表明调控突变与物种水平的进化变化直接相关。虽然先前已经显示出几个基因影响拟南芥开花时间的自然变化，但大多数基因要么显示蛋白质编码变化，要么以低频率（<5%）发现。在这里，我们确定和表征自然变异的顺式调控序列的转录因子CONSTANS的基础开花时间的多样性在拟南芥。在这个调控基序的突变最近演变，并已蔓延到高频率在拟南芥的自然加入，这表明这些顺式调节变化的适应性变化的开花时间的作用。 转录因子CONSTANS调节拟南芥开花的时间。罗萨斯等人报道，该基因顺式调节区的遗传变异有助于开花时间的自然表型变异。
The onset of flowering, the change from vegetative to reproductive development, is a major life history transition in flowering plants. Recent work suggests that mutations in cis-regulatory mutations should play critical roles in the evolution of this (as well as other) important adaptive traits, but thus far there has been little evidence that directly links regulatory mutations to evolutionary change at the species level. While several genes have previously been shown to affect natural variation in flowering time in Arabidopsis thaliana, most either show protein-coding changes and/or are found at low frequency (<5%). Here we identify and characterize natural variation in the cis-regulatory sequence in the transcription factor CONSTANS that underlies flowering time diversity in Arabidopsis. Mutation in this regulatory motif evolved recently and has spread to high frequency in Arabidopsis natural accessions, suggesting a role for these cis-regulatory changes in adaptive variation of flowering time. The transcription factor CONSTANS regulates the timing of flowering in Arabidopsis. Rosas et al. report that genetic variation in the cis-regulatory regions of this gene contributes to natural phenotypic variation in flowering time.
登录
查看更多内容
影响因子：
9.8
作者：
Rosas U;Barton NH;Copsey L;Barbier de Reuille P;Coen E
通讯作者：
Coen E
影响因子：
56.9
作者：
Johanson, U;West, J;Dean, C
通讯作者：
Dean, C
影响因子：
11.6
作者：
Michaels, SD;Amasino, RM
通讯作者：
Amasino, RM
影响因子：
8.8
作者：
Banta, Joshua A.;Ehrenreich, Ian M.;Purugganan, Michael D.
通讯作者：
Purugganan, Michael D.
影响因子：
10.7
作者：
Flowers, Jonathan M.;Hanzawa, Yoshie;Purugganan, Michael D.
通讯作者：
Purugganan, Michael D.