Random and Non‐Random Coincidence Between Luteinizing Hormone Peaks and Follicle‐Stimulating Hormone, Alpha Subunit, Prolactin and Gonadotropin‐Releasing Hormone ulsations
Random and Non‐Random Coincidence Between Luteinizing Hormone Peaks and Follicle‐Stimulating Hormone, Alpha Subunit, Prolactin and Gonadotropin‐Releasing Hormone ulsations
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黄体生成激素峰值与卵泡刺激激素、α 亚基、催乳素和促性腺激素释放激素波动之间的随机和非随机一致性
DOI：
10.1111/j.1365-2826.1989.tb00101.x
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发表时间：
1989
影响因子：
3.2
通讯作者：
Michael L. Johnson
中科院分区：
文献类型：
--
作者：
J. Veldhuis;A. Iranmanesh;L. Clarke;D. Kaiser;Michael L. Johnson
我们检查了正常男性中黄体生成素 (LH) 和催乳素、LH 和卵泡刺激素 (FSH) 以及 LH 和 α 亚基的共搏动性。我们测试了生理观察到的共搏动程度（峰值重合）是否显着超过独立搏动激素系列之间预期的随机一致性。为此，使用计算机模拟来创建以已知频率随机且独立脉动的合成内分泌时间序列。对随机重合峰值数量的均值、方差和概率分布的预测结果使我们能够检验零假设，即生理上观察到的激素共脉冲性仅归因于机会峰值关联。对 33 名正常男性和 6 只接受下丘脑垂体联合颈静脉导管插入术的卵巢切除母羊进行了生理观察。获得了以下显着结果：1）在高脉冲频率下，独立脉冲激素系列之间的随机峰值重合率很大，但在促性腺激素释放激素和 LH 峰值的情况下，这种随机率显着超过（P<0.0001）； 2) 当重合被定义为不仅同时出现而且在某个定义的时间窗口内出现的峰值最大值时（例如±10分钟，如文献中通常所做的那样），随机重合进一步增加； 3) 正常男性中 LH 和 FSH 同时脉动可表现出显着的共搏动性 (P< 0.0001)； 4) 10 分钟滞后（但不是同时）LH 和催乳素脉冲的符合率明显高于偶然关联； 5)观察到的LH和亚基脉冲之间的重合显着超过预期（随机）峰值重叠（P<0.001）； 6）相比之下，不同男性的激素峰值只是随机相关的。
We have examined the co‐pulsatility of luteinizing hormone (LH) and prolactin, LH and follicle‐stimulating hormone (FSH), and LH and α subunit in normal men. We tested whether the degree of physiologically observed co‐pulsatility (peak coincidence) significantly exceeded expected random concordance between independently pulsating hormone series. To this end, computer simulations were used to create synthetic endocrine time series pulsating randomly and independently at known frequencies. Resultant predictions of the mean, variance and probability distribution of the number of randomly coincident peaks permitted us to test the null hypothesis that physiologically observed hormone co‐pulsatility was due to chance peak associations alone. Physiological observations were made in 33 normal men and in six ovariectomized ewes subjected to combined hypothalamo‐pituitary and jugular venous catheterization. The following salient results were obtained: 1) random peak coincidence rates between independently pulsating hormone series were substantial at high pulse frequencies, but such random rates were significantly exceeded in the case of gonadotropin‐releasing hormone and LH peaks (P< 0.0001); 2) random coincidence was further increased when coincidence was defined as peak maxima occurring not only simultaneously but also within some defined time window (e.g. ±10 min, as commonly done in the literature); 3) significant co‐pulsatility could be demonstrated for simultaneous LH and FSH pulsations in normal men (P< 0.0001); 4) coincidence rates for 10‐min lagged (but not for simultaneous) LH and prolactin pulses were significantly more likely than chance associations; 5) observed coincidence between LH and a subunit pulses significantly exceeded expected (random) peak overlap (P<0.001); and 6) in contrast, hormone peaks in different men were only randomly associated.
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DOI：
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发表时间：
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DOI：
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发表时间：
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DOI：
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发表时间：
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期刊：
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影响因子：
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影响因子：
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