Unequivocal identification of brown adipose tissue in a human infant.
Unequivocal identification of brown adipose tissue in a human infant.
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DOI：
10.1002/jmri.23531
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发表时间：
2012-04
影响因子：
4.4
通讯作者：
Gilsanz, Vicente
中科院分区：
文献类型：
--
作者：
Hu, Houchun H.;Tovar, Jason P.;Pavlova, Zdena;Smith, Michelle L.;Gilsanz, Vicente
我们报告了一个三个月大的婴儿通过MRI和计算机断层扫描（CT）对棕色脂肪组织（BAT）的独特描述。基于BAT和更富含脂质的白色脂肪组织（WAT）之间的细胞差异，化学位移MRI和CT都能够在两种组织之间以及与周围解剖结构之间产生不同的信号对比，前者利用脂肪信号分数度量，后者利用X射线衰减值。虽然之前已经在啮齿动物中进行了许多BAT成像实验，但直到最近才在成人中用融合正电子发射和计算机断层扫描描述了人类中BAT的识别。BAT在儿童中的成像尚未被广泛报道，此外，人类BAT的MRI一般尚未得到证实。在目前的工作中，大的双侧锁骨上BAT仓库清楚地可视化与MRI和CT。随后通过组织学确认了组织身份。BAT在调节能量代谢和非颤抖性产热方面具有重要意义，并有可能对抗体重增加和肥胖的发展。目前的研究结果表明，BAT在儿童中存在大量，MRI和CT可以根据内在组织特性区分BAT和WAT。
We report the unique depiction of brown adipose tissue (BAT) by MRI and computed tomography (CT) in a human three month-old infant. Based on cellular differences between BAT and more lipid-rich white adipose tissue (WAT), chemical-shift MRI and CT were both capable of generating distinct signal contrasts between the two tissues and against surrounding anatomy, utilizing fat-signal fraction metrics in the former and X-ray attenuation values in the latter. While numerous BAT imaging experiments have been performed previously in rodents, the identification of BAT in humans has only recently been described with fusion positron emission and computed tomography in adults. The imaging of BAT in children has not been widely reported and furthermore, MRI of human BAT in general has not been demonstrated. In the present work, large bilateral supraclavicular BAT depots were clearly visualized with MRI and CT. Tissue identity was subsequently confirmed by histology. BAT has important implications in regulating energy metabolism and non-shivering thermogenesis and has the potential to combat the onset of weight gain and the development of obesity. Current findings suggest that BAT is present in significant amounts in children and that MRI and CT can differentiate BAT from WAT based on intrinsic tissue properties.
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影响因子：
3.3
作者：
Branca RT;Warren WS
通讯作者：
Warren WS
影响因子：
4.4
作者：
Hu, Houchun H.;Smith, Daniel L., Jr.;Nayak, Krishna S.;Goran, Michael I.;Nagy, Tim R.
通讯作者：
Nagy, Tim R.
DOI：
10.1679/aohc1950.38.43
发表时间：
1975-01-01
期刊：
ARCHIVUM HISTOLOGICUM JAPONICUM
影响因子：
--
作者：
TANUMA, Y;YAMAMOTO, M;YOKOCHI, C
通讯作者：
YOKOCHI, C
影响因子：
158.5
作者：
Virtanen, Kirsi A.;Lidell, Martin E.;Nuutila, Pirjo
通讯作者：
Nuutila, Pirjo
影响因子：
2.3
作者：
Gelfand, MJ;O'Hara, SM;MacLean, JR
通讯作者：
MacLean, JR