Tumor-infiltrating FoxP3(+) Tregs predict favorable outcome in colorectal cancer patients: A meta-analysis.
Tumor-infiltrating FoxP3(+) Tregs predict favorable outcome in colorectal cancer patients: A meta-analysis.
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DOI：
10.18632/oncotarget.17722
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发表时间：
2017-09-26
期刊：
影响因子：
--
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Hu G;Li Z;Wang S
Foxp3+调节性T细胞(FoxP3+Tregs)被认为是免疫逃逸和肿瘤进展的关键介质。然而，FoxP3+Tregs在人类结直肠癌(CRC)中的作用仍存在争议。在这里，我们进行了一项荟萃分析，包括17项已发表的研究，涉及来自PubMed和EBSCO的3811名患者，以评估肿瘤浸润性FoxP3+Tregs对人类结直肠癌预后的影响。研究发现，FoxP3+Tregs的表达与患者1、3、5、10年总生存期(OS)呈显著正相关，而与1、3、5年无瘤生存期(DFS)无明显相关性。有趣的是，在按肿瘤内FoxP3+Tregs渗入的间隔进行的分层分析中，FoxP3+Tregs侵入间质间质明显改善了3年和5年的OS，而当FoxP3+Tregs仅渗透到上皮内时，OS没有改善。此外，FoxP3+Tregs同时侵犯上皮内和间质与结直肠癌的TNM分期呈显著负相关。结论：肿瘤内高密度的FoxP3+Tregs尤其是间质内高密度的FoxP3+Tregs有助于结直肠癌的预后，提示FoxP3+Tregs是判断结直肠癌预后的有价值的指标之一。
FoxP3+ regulatory T cells (FoxP3+ Tregs) are considered to be a key mediator in immune escape and tumor progression. However, the role of FoxP3+ Tregs in human colorectal cancer (CRC) remains controversial. Herein, we conducted a meta-analysis including 17 published studies with 3811 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating FoxP3+ Tregs in human CRC. We found FoxP3+ Tregs infiltrating into both intraepithelium and stroma within tumor were significantly positively correlated with 1, 3, 5 and 10-year overall survival (OS), but not with 1, 3, 5-year disease-free survival (DFS) of patients. Interestingly, in stratified analyses by compartments within tumor FoxP3+ Tregs infiltrating into, FoxP3+ Tregs invading stromal compartment significantly improved 3 and 5-year OS, yet OS wasn’t improved when FoxP3+ Tregs infiltrated into intraepithelium only. Furthermore, FoxP3+ Tregs invading both intraepithelium and stroma significantly inversely correlated with TNM stage of CRC. In conclusion, High density of FoxP3+ Tregs within tumor especially at stromal compartment leads to a favorable outcome in CRC, implicating FoxP3+ Tregs are one of valuable indexes for prognostic prediction in human CRC.
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