Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer.
Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer.
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DOI：
10.1371/journal.pone.0053630
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gasser M
中科院分区：
文献类型：
--
作者：
Kim M;Grimmig T;Grimm M;Lazariotou M;Meier E;Rosenwald A;Tsaur I;Blaheta R;Heemann U;Germer CT;Waaga-Gasser AM;Gasser M
表达转录因子叉头盒蛋白P3 （Foxp3）的调节性T细胞（Treg）已被确定在肿瘤进展过程中抵消抗肿瘤免疫反应。此外，癌细胞自身呈现的Foxp3也可能使它们能够逃避效应t细胞的反应，从而使肿瘤存活。对于结直肠癌（CRC）， Foxp3的临床相关性尚未得到详细评估。因此，本研究的目的是研究其对结直肠癌（CRC）的影响。通过对结直肠癌患者肿瘤组织进行基因和蛋白分析，量化Foxp3在肿瘤浸润Treg和结肠癌细胞中的表达。结果与临床病理参数及患者总生存期相关。连续形态学分析表明Foxp3在癌细胞中表达。与Foxp3低表达的患者相比，Foxp3高表达的患者预后较差。相比之下，肿瘤浸润Treg细胞中Foxp3水平的高低在患者总体生存率上无显著差异。我们的研究结果强烈表明，Foxp3的表达是由癌细胞介导的，而不是由Treg细胞介导的，这有助于疾病的进展。
Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also allow them to evade from effector T-cell responses, resulting in a survival benefit of the tumor. For colorectal cancer (CRC) the clinical relevance of Foxp3 has not been evaluated in detail. Therefore the aim of this study was to study its impact in colorectal cancer (CRC). Gene and protein analysis of tumor tissues from patients with CRC was performed to quantify the expression of Foxp3 in tumor infiltrating Treg and colon cancer cells. The results were correlated with clinicopathological parameters and patients overall survival. Serial morphological analysis demonstrated Foxp3 to be expressed in cancer cells. High Foxp3 expression of the cancer cells was associated with poor prognosis compared to patients with low Foxp3 expression. In contrast, low and high Foxp3 level in tumor infiltrating Treg cells demonstrated no significant differences in overall patient survival. Our findings strongly suggest that Foxp3 expression mediated by cancer cells rather than by Treg cells contribute to disease progression.
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影响因子：
3.8
作者：
Ladoire, Sylvain;Arnould, Laurent;Ghiringhelli, Francois
通讯作者：
Ghiringhelli, Francois
影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
DOI：
10.1097/cji.0b013e3181d32f01
发表时间：
2010-05
期刊：
Journal of immunotherapy (Hagerstown, Md. : 1997)
影响因子：
--
作者：
Correale P;Rotundo MS;Del Vecchio MT;Remondo C;Migali C;Ginanneschi C;Tsang KY;Licchetta A;Mannucci S;Loiacono L;Tassone P;Francini G;Tagliaferri P
通讯作者：
Tagliaferri P
影响因子：
5.3
作者：
Tao, Hiroyuki;Mimura, Yusuke;Ueoka, Hiroshi
通讯作者：
Ueoka, Hiroshi
DOI：
10.1073/pnas.0509182102
发表时间：
2005-12-20
影响因子：
11.1
作者：
Sato, E;Olson, SH;Odunsi, K
通讯作者：
Odunsi, K