Expression of Transforming Growth Factor &bgr;1 in Ameloblastomas
Expression of Transforming Growth Factor &bgr;1 in Ameloblastomas
复制标题
转化生长因子的表达
DOI：
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
F. Carinci
中科院分区：
文献类型：
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作者：
G. Iezzi;A. Piattelli;C. Rubini;L. Artese;G. Goteri;V. Perrotti;F. Carinci
本研究旨在通过免疫组化方法比较转化生长因子（TGF）1在不同复发风险的成釉细胞瘤（AM）中的表达。共对29例AM进行了评价。将肿瘤分为2组：A组（10例）由单囊和外周AM组成，与复发风险低相关，B组（19例）由实体AM组成，与复发风险高相关。统计学评价显示A组和B组病变之间存在显著差异，B组肿瘤中基质细胞中TGF- 1的阳性值较高（P = 0.0308）。两组间血管和牙源性上皮的免疫反应性差异无统计学意义。复发风险高的肿瘤中TGF- 1表达增加可以用以下事实来解释：尽管TGF-在肿瘤进展的早期阶段充当有效的肿瘤抑制因子，但后来它似乎增强了肿瘤的侵袭性表型。
The aim of the present study was to compare the expression of transforming growth factor (TGF) &bgr;1 in ameloblastomas (AMs) with different risk of recurrence by immunohistochemistry. A total of 29 cases of AMs were evaluated. The tumors were divided into 2 groups: group A (10 cases) composed of unicystic and peripheral AMs, associated with a low risk of recurrence, and group B (19 cases) composed of solid AMs, associated with a high risk of recurrence. Statistical evaluation showed significant differences between groups A and B lesions, with higher values of positivity for TGF-&bgr;1 in stromal cells in group B tumors (P = 0.0308). No statistically significant differences of immunoreactivity were found in vessels and odontogenic epithelium between the 2 groups. The increased TGF-&bgr;1 expression in tumors with a high risk of recurrence could be explained with the fact that although TGF-&bgr; acts as a potent tumor suppressor in the early stages of tumor progression, later it seems to enhance the invasive phenotype of the tumor.
影响因子：
8.7
作者：
S. Wahl;J. Wen;N. Moutsopoulos
通讯作者：
S. Wahl;J. Wen;N. Moutsopoulos
人根周病变中嗜酸性粒细胞衍生的转化生长因子（TGF-α 和 TGF-β 1）。
DOI：
10.1016/s0099-2399(99)80322-7
发表时间：
1999
期刊：
Journal of endodontics.
影响因子：
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作者：
Tyler,LW;Matossian,K;Todd,R;Gallagher,GT;White,RR;Wong,DT
通讯作者：
Wong,DT