A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins [published erratum appears in J Exp Med 1991 Sep 1;174(3):753]
A human mannose-binding protein is an acute-phase reactant that shares sequence homology with other vertebrate lectins [published erratum appears in J Exp Med 1991 Sep 1;174(3):753]
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人甘露糖结合蛋白是一种急性期反应物，与其他脊椎动物凝集素具有序列同源性[已发表的勘误表出现在 J Exp Med 1991 Sep 1;174(3):753]
DOI：
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复制
发表时间：
1988
影响因子：
15.3
通讯作者：
Herman
中科院分区：
文献类型：
--
作者：
By;B. Alan;Ezekowitz;E. Linda;Day;Gary;Herman
甘露糖结合蛋白已从大鼠和人的肝脏中分离出来，随后在大鼠、兔和人的血清中发现。我们报告分离的cDNA克隆分离的人肝cDNA文库编码的人甘露糖结合蛋白。一级结构具有三个结构域：（a）19个氨基酸的NH 2-末端富含半胱氨酸的区段，其似乎参与链间二硫键的形成，所述链间二硫键将稳定蛋白质的多聚体形式;（B）由序列Gly-x-y的19个重复组成的胶原蛋白样区;和（c）由148个残基组成的COOH-末端推定的碳水化合物结合结构域。这种人甘露糖结合蛋白与大鼠甘露糖结合蛋白C具有51%的总体同源性（允许三个缺口），与大鼠甘露糖结合蛋白A具有48%的同源性（允许七个缺口）。像这些同源的大鼠蛋白质，人甘露糖结合蛋白COOH-末端序列是同源的碳水化合物识别部分的其他几个凝集素样蛋白质，包括哺乳动物肝受体，昆虫可溶性血淋巴，和海胆凝集素体腔液中发现。狗和人表面活性剂的脱辅基蛋白和人淋巴细胞IgE Ec受体尚未显示出具有凝集素样性质，但通过同源性是该凝集素样蛋白家族的成员。人甘露糖结合蛋白之前是典型的疏水信号序列，并且其肝分泌作为急性期应答的一部分被诱导，这与其在宿主防御中的可能作用一致。
Mannose-binding proteins have been isolated from the liver of rats and humans and subsequently been found in the serum of rats, rabbits, and humans. We report the isolation of cDNA clones isolated from a human liver cDNA library that encodes a human mannose-binding protein. The primary structure has three domains: (a) an NH2-terminal cysteine-rich segment of 19 amino acids which appears to be involved in the formation of interchain disulfide bonds that would stabilize multimeric forms of the protein; (b) a collagen-like region consisting of 19 repeats of the sequence Gly-x-y; and (c) a COOH-terminal putative carbohydrate-binding domain consisting of 148 residues. This human mannose-binding protein bears 51% overall homology (allowing three gaps) with a rat mannose- binding protein C and 48% homology (allowing seven gaps) with a rat mannose-binding protein A. Like these homologous rat proteins, the human mannose-binding protein COOH-terminal sequences are homologous to the carbohydrate recognition portion of several other lectin-like proteins including mammalian hepatic receptors, an insect-soluble hemolymph, and a sea urchin lectin found in coelomic fluid. The apoproteins of dog and human surfactant and the human lymphocyte IgE Ec receptor have not been shown to have lectin-like properties, yet by homology are members of this family of lectin-like proteins. The human mannose-binding protein is preceded by a typical hydrophobic signal sequence and its hepatic secretion is induced as part of the acute- phase response consistent with its probable role in host defense.
大鼠肝细胞中甘露糖和 N-乙酰氨基葡萄糖特异性凝集素的表征。
DOI：
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发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Maynard,Y;Baenziger,JU
通讯作者：
Baenziger,JU
DOI：
10.1073/pnas.82.19.6374
发表时间：
1985-01-01
影响因子：
11.1
作者：
KARATHANASIS, SK
通讯作者：
KARATHANASIS, SK