Vitamin D Deficiency and Outcome of COVID-19 Patients.
Vitamin D Deficiency and Outcome of COVID-19 Patients.
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DOI：
10.3390/nu12092757
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发表时间：
2020-09-10
期刊：
影响因子：
5.9
通讯作者：
Merle U
中科院分区：
文献类型：
--
作者：
Radujkovic A;Hippchen T;Tiwari-Heckler S;Dreher S;Boxberger M;Merle U
严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）感染对全世界的卫生保健系统构成了巨大挑战。在没有因果关系治疗的情况下，识别可改变的预后因素可能有助于改善预后。为了探索维生素D（VitD）状态与疾病严重程度和生存率的可能关联，我们研究了185名被诊断患有2019冠状病毒病（COVID-19）并在我们中心接受治疗的患者。使用认可的实验室方法回顾性评估首次就诊时的维生素D状态。维生素D缺乏定义为血清总25-羟基维生素D水平< 12 ng/mL（<30 nM）。主要终点为严重病程（即，需要有创机械通气和/或死亡，IMV/D）。在中位观察期66天（范围2-92天）内，23例患者需要IMV。共有28例患者患有IMV/D，其中16例死亡。93例（50%）患者需要住院治疗（住院亚组）。共有41例（22%）患者维生素D缺乏。当调整年龄、性别和合并症后，维生素D缺乏与IMV/D和死亡的风险较高相关（HR分别为6.12，95% CI 2.79-13.42，p < 0.001和HR 14.73，95% CI 4.16-52.19，p < 0.001）。在住院患者亚组中观察到类似的相关性。我们的研究证明了维生素D缺乏与COVID-19的严重程度/死亡率之间的关联，强调了对SARS-CoV-2感染者补充维生素D进行干预研究的必要性。
Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin D (VitD) status with disease severity and survival, we studied 185 patients diagnosed with coronavirus disease 2019 (COVID-19) and treated at our center. VitD status at first presentation was assessed retrospectively using accredited laboratory methods. VitD deficiency was defined as serum total 25-hydroxyvitamin D level < 12 ng/mL (<30 nM). Primary endpoint was severe course of disease (i.e., need for invasive mechanical ventilation and/or death, IMV/D). Within a median observation period of 66 days (range 2–92), 23 patients required IMV. A total of 28 patients had IMV/D, including 16 deaths. Ninety-three (50%) patients required hospitalization (inpatient subgroup). A total of 41 (22%) patients were VitD deficient. When adjusted for age, gender, and comorbidities, VitD deficiency was associated with higher risk of IMV/D and death (HR 6.12, 95% CI 2.79–13.42, p < 0.001 and HR 14.73, 95% CI 4.16–52.19, p < 0.001, respectively). Similar correlations were observed in the inpatient subgroup. Our study demonstrates an association between VitD deficiency and severity/mortality of COVID-19, highlighting the need for interventional studies on VitD supplementation in SARS-CoV-2 infected individuals.
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影响因子：
168.9
作者：
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10.1136/bmj.i6583
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DOI：
10.1016/s1473-3099(20)30243-7
发表时间：
2020-06-01
期刊：
The Lancet. Infectious diseases
影响因子：
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作者：
Verity, Robert;Okell, Lucy C;Ferguson, Neil M
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影响因子：
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作者：
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通讯作者：
Urcuqui-Inchima, Silvio