Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases.
Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases.
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DOI：
10.3390/jcdd10040166
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发表时间：
2023-04-12
影响因子：
2.4
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中科院分区：
文献类型：
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非编码RNA（ncRNA）在心脏发育和心血管疾病（CVD）中发挥重要作用，心血管疾病是发病率和死亡率的主要原因。随着RNA测序技术的进步，最近的研究重点已经从特定候选人的研究过渡到全转录组分析。得益于这些类型的研究，新的ncRNA因其在心脏发育和心血管疾病中的作用而被发现。在这篇综述中，我们简要介绍了ncRNA的分类为microRNA，长ncRNA和环状RNA。然后，我们通过引用最新的研究文章来讨论它们在心脏发育和心血管疾病中的关键作用。更具体地说，我们总结了ncRNA在心管和心脏形态发生，心脏中胚层特化，胚胎心肌细胞和心脏祖细胞的形成中的作用。我们还强调了最近出现的ncRNA作为心血管疾病的关键调节因子，重点关注其中的六个。我们认为，这篇综述简明扼要地阐述了心脏发育和心血管疾病中ncRNA研究目前进展的主要方面。因此，这篇综述将有利于读者获得关键ncRNA及其在心脏发育和心血管疾病中的作用机制的最新图片。
Noncoding RNAs (ncRNAs) play fundamental roles in cardiac development and cardiovascular diseases (CVDs), which are a major cause of morbidity and mortality. With advances in RNA sequencing technology, the focus of recent research has transitioned from studies of specific candidates to whole transcriptome analyses. Thanks to these types of studies, new ncRNAs have been identified for their implication in cardiac development and CVDs. In this review, we briefly describe the classification of ncRNAs into microRNAs, long ncRNAs, and circular RNAs. We then discuss their critical roles in cardiac development and CVDs by citing the most up-to-date research articles. More specifically, we summarize the roles of ncRNAs in the formation of the heart tube and cardiac morphogenesis, cardiac mesoderm specification, and embryonic cardiomyocytes and cardiac progenitor cells. We also highlight ncRNAs that have recently emerged as key regulators in CVDs by focusing on six of them. We believe that this review concisely addresses perhaps not all but certainly the major aspects of current progress in ncRNA research in cardiac development and CVDs. Thus, this review would be beneficial for readers to obtain a recent picture of key ncRNAs and their mechanisms of action in cardiac development and CVDs.
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影响因子：
3
作者：
Cai, Haijian;Fan, Shiqian;Cai, Luqiong;Zhu, Lin;Zhao, Zhucheng;Li, Yaozhe;Yao, Yizhu;Huang, Xiaoying;Wang, Liangxing
通讯作者：
Wang, Liangxing
影响因子：
2.7
作者：
Jiang H;Gong R;Wu Y
通讯作者：
Wu Y
DOI：
10.1186/s12964-022-00993-2
发表时间：
2022-11-21
期刊：
Cell communication and signaling : CCS
影响因子：
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DOI：
10.1161/circheartfailure.121.008686
发表时间：
2022-04
期刊：
Circulation. Heart failure
影响因子：
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作者：
Aonuma T;Moukette B;Kawaguchi S;Barupala NP;Sepúlveda MN;Frick K;Tang Y;Guglin M;Raman SV;Cai C;Liangpunsakul S;Nakagawa S;Kim IM
通讯作者：
Kim IM
DOI：
10.1183/13993003.00012-2022
发表时间：
2022-12
期刊：
The European respiratory journal
影响因子：
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