How vascular smooth muscle cell phenotype switching contributes to vascular disease.
How vascular smooth muscle cell phenotype switching contributes to vascular disease.
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DOI：
10.1186/s12964-022-00993-2
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发表时间：
2022-11-21
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血管平滑肌细胞（VSMCs）是血管中最丰富的细胞。早期的实验发现VSMCs具有很高的可塑性。血管损伤刺激VSMCs转换为去分化型，也称为合成VSMCs，具有高迁移和增殖能力，可修复血管损伤。近年来，主要由于单细胞测序和细胞谱系追踪技术的快速发展，在血管老化、动脉粥样硬化（AS）、主动脉瘤（AA）等疾病中发现了多种VSMCs表型。这些VSMCs均下调α-SMA和calponin1等收缩性蛋白，获得成骨细胞、成纤维细胞、巨噬细胞和间充质细胞的特异性标记和类似的细胞功能。这种高度可塑性的表型转化是由循环血浆物质、转录因子、生长因子、炎症因子、非编码rna、整合素家族和Notch通路组成的复杂网络调控的。本文就VSMCs表型景观的表型特征、分子特征及其功能作用作一综述；调控VSMCs表型转换的分子机制；以及VSMCs表型转换对血管老化、AS和AA的贡献。视频摘要在线版本包含补充材料，可在10.1186/s12964-022-00993-2获得。
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs possess high plasticity. Vascular injury stimulates VSMCs to switch into a dedifferentiated type, also known as synthetic VSMCs, with a high migration and proliferation capacity for repairing vascular injury. In recent years, largely owing to rapid technological advances in single-cell sequencing and cell-lineage tracing techniques, multiple VSMCs phenotypes have been uncovered in vascular aging, atherosclerosis (AS), aortic aneurysm (AA), etc. These VSMCs all down-regulate contractile proteins such as α-SMA and calponin1, and obtain specific markers and similar cellular functions of osteoblast, fibroblast, macrophage, and mesenchymal cells. This highly plastic phenotype transformation is regulated by a complex network consisting of circulating plasma substances, transcription factors, growth factors, inflammatory factors, non-coding RNAs, integrin family, and Notch pathway. This review focuses on phenotypic characteristics, molecular profile and the functional role of VSMCs phenotype landscape; the molecular mechanism regulating VSMCs phenotype switching; and the contribution of VSMCs phenotype switching to vascular aging, AS, and AA. Video Abstract The online version contains supplementary material available at 10.1186/s12964-022-00993-2.
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DOI：
10.1161/atvbaha.120.315164
发表时间：
2021-01
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Chattopadhyay A;Kwartler CS;Kaw K;Li Y;Kaw A;Chen J;LeMaire SA;Shen YH;Milewicz DM
通讯作者：
Milewicz DM
影响因子：
4.8
作者：
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Liaw, Lucy
影响因子：
4.8
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Byon, Chang Hyun;Javed, Amjad;Chen, Yabing
通讯作者：
Chen, Yabing
影响因子：
5.3
作者：
Andreeva, ER;Pugach, IM;Orekhov, AN
通讯作者：
Orekhov, AN
DOI：
10.1161/atvbaha.118.311298
发表时间：
2018-09-01
影响因子：
8.7
作者：
Badi, Ileana;Mancinelli, Luigi;Raucci, Angela
通讯作者：
Raucci, Angela