Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy.
Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy.
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DOI：
10.1002/glia.21185
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发表时间：
2011-08
期刊：
影响因子：
6.2
通讯作者：
Rich, Jeremy N.
中科院分区：
文献类型：
--
作者：
Venere, Monica;Fine, Howard A.;Dirks, Peter B.;Rich, Jeremy N.
神经肿瘤学研究通过将细胞异质性纳入具有干细胞特征的细胞亚群的肿瘤模型，重新发现了神经系统癌症的复杂性。自我更新的癌症干细胞（CSCs）可以增殖肿瘤并产生非致瘤性肿瘤大细胞，显示出更分化的表型。前瞻性分离和询问CSCs的能力正在定义负责肿瘤维持和生长的分子机制。CSCs对细胞毒性治疗的抵抗和促进肿瘤血管生成的作用支持了其临床相关性。虽然CSC生物学领域相对年轻，但对这些细胞特征的持续阐明为开发新的患者治疗方法带来了希望。
Neuro-oncology research has rediscovered a complexity of nervous system cancers through the incorporation of cellular heterogeneity into tumor models with cellular subsets displaying stem cell characteristics. Self-renewing cancer stem cells (CSCs) can propagate tumors and yield non-tumorigenic tumor bulk cells that display a more differentiated phenotype. The ability to prospectively isolate and interrogate CSCs is defining molecular mechanisms responsible for the tumor maintenance and growth. The clinical relevance of CSCs has been supported by their resistance to cytotoxic therapies and their promotion of tumor angiogenesis. Although the field of CSC biology is relatively young, continued elucidation of the features of these cells holds promise for the development of novel patient therapies.
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影响因子：
11.2
作者：
Folkins C;Shaked Y;Man S;Tang T;Lee CR;Zhu Z;Hoffman RM;Kerbel RS
通讯作者：
Kerbel RS
影响因子：
11.2
作者：
Harris MA;Yang H;Low BE;Mukherjee J;Guha A;Bronson RT;Shultz LD;Israel MA;Yun K
通讯作者：
Yun K
DOI：
10.4161/cc.8.20.9701
发表时间：
2009-10-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Heddleston JM;Li Z;McLendon RE;Hjelmeland AB;Rich JN
通讯作者：
Rich JN
影响因子：
12.4
作者：
Eramo, A.;Lotti, F.;De Maria, R.
通讯作者：
De Maria, R.
影响因子：
11.2
作者：
Galli, R;Binda, E;Vescovi, A
通讯作者：
Vescovi, A