The role of the complosome in health and disease.
The role of the complosome in health and disease.
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DOI：
10.3389/fimmu.2023.1146167
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发表时间：
2023
影响因子：
7.3
通讯作者：
He, Songqing
中科院分区：
文献类型：
--
作者：
Xiao, Fang;Guo, Jixu;Tomlinson, Stephen;Yuan, Guandou;He, Songqing
补体系统是免疫系统最古老的防御机制之一，历史上被认为是肝源性和血清活性的先天免疫系统，其“补充”针对病原体的细胞介导和抗体介导的免疫应答。然而，补体系统现在被认为是系统和局部组织水平上的先天性和适应性免疫的核心组成部分。越来越多的发现揭示了细胞内活性补体系统--补体体--的新活动，这改变了该领域已建立的功能模式。已证明补体在调节T细胞反应，细胞生理学（如代谢），炎症疾病过程和癌症中发挥关键作用，这充分证明了其巨大的研究潜力，并告诉我们，关于这个系统还有很多东西要学。在这里，我们总结了目前的理解，并讨论了在健康和疾病的复杂体的新兴作用。
The complement system is one of the immune system’s oldest defense mechanisms and is historically regarded as a liver-derived and serum-active innate immune system that ‘complements’ cell-mediated and antibody-mediated immune responses against pathogens. However, the complement system is now recognized as a central component of both innate and adaptive immunity at both the systemic and local tissue levels. More findings have uncovered novel activities of an intracellularly active complement system—the complosome—that have shifted established functional paradigms in the field. The complosome has been shown to play a critical function in regulating T cell responses, cell physiology (such as metabolism), inflammatory disease processes, and cancer, which has amply proved its immense research potential and informed us that there is still much to learn about this system. Here, we summarize current understanding and discuss the emerging roles of the complosome in health and disease.
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影响因子：
16.6
作者：
Arbore G;West EE;Rahman J;Le Friec G;Niyonzima N;Pirooznia M;Tunc I;Pavlidis P;Powell N;Li Y;Liu P;Servais A;Couzi L;Fremeaux-Bacchi V;Placais L;Ferraro A;Walsh PR;Kavanagh D;Afzali B;Lavender P;Lachmann HJ;Kemper C
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32.4
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4.6
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影响因子：
64.5
作者：
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通讯作者：
Pearce EL
影响因子：
7.3
作者：
Kremlitzka, Mariann;Nowacka, Alicja A.;Blom, Anna M.
通讯作者：
Blom, Anna M.