Effects of Berberine on the Gastrointestinal Microbiota.

Effects of Berberine on the Gastrointestinal Microbiota.
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小檗碱对胃肠道微生物群的影响

DOI:
10.3389/fcimb.2020.588517
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发表时间:
2020
影响因子:
5.7
通讯作者:
Wang L
Wang L
中科院分区:
医学2区
文献类型:
--
作者:
Zhang L;Wu X;Yang R;Chen F;Liao Y;Zhu Z;Wu Z;Sun X;Wang L

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胃肠道微生物群是一个多方面的系统,正在揭示多种疾病发生和进展的新因素。在中国,小檗碱已被用于治疗肥胖、糖尿病、动脉粥样硬化和代谢性疾病。还有关于小檗碱用于心血管、胃肠道和内分泌疾病的临床试验。小檗碱在标准剂量下即可产生临床益处,并且毒性较低。小檗碱在降脂和胰岛素抵抗中的作用机制尚不完全清楚,但可能的机制之一与其对胃肠道微生物群的影响有关。通过对电子数据库(PubMed、Scopus、Embase、Web of Sciences、Science Direct)的广泛搜索,确定了胃肠道微生物群在小檗碱治疗中的作用。本综述的目的是总结小檗碱通过调节胃肠道微生物群对动物和人类的药理作用。
The gastrointestinal microbiota is a multi-faceted system that is unraveling novel contributors to the development and progression of several diseases. Berberine has been used to treat obesity, diabetes mellitus, atherosclerosis, and metabolic diseases in China. There are also clinical trials regarding berberine use in cardiovascular, gastrointestinal, and endocrine diseases. Berberine elicits clinical benefits at standard doses and has low toxicity. The mechanism underlying the role of berberine in lipid‐lowering and insulin resistance is incompletely understood, but one of the possible mechanisms is related to its effect on the gastrointestinal microbiota. An extensive search in electronic databases (PubMed, Scopus, Embase, Web of Sciences, Science Direct) was used to identify the role of the gastrointestinal microbiota in the berberine treatment. The aim of this review was to summarize the pharmacologic effects of berberine on animals and humans by regulation of the gastrointestinal microbiota.
DOI: 10.2174/0929867323666160411143314
发表时间: 2016-01-01
影响因子: 4.1
作者:
Caliceti, Cristiana;Franco, Placido;Cicero, Arrigo F. G.
通讯作者: Cicero, Arrigo F. G.
小檗碱减轻 2 型糖尿病大鼠的肠粘膜屏障功能障碍
DOI: 10.3389/fphar.2017.00042
发表时间: 2017
影响因子: 5.6
作者:
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DOI: 10.1186/s12906-016-1367-7
发表时间: 2016-10-18
影响因子: --
作者:
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通讯作者: Klaassen CD
DOI: 10.1136/gutjnl-2016-313432
发表时间: 2018-05-01
期刊: GUT
影响因子: 24.5
作者:
Grander, Christoph;Adolph, Timon E.;Tilg, Herbert
通讯作者: Tilg, Herbert
DOI: 10.1073/pnas.1219451110
发表时间: 2013-05-28
影响因子: 11.1
作者:
Everard, Amandine;Belzer, Clara;Cani, Patrice D.
通讯作者: Cani, Patrice D.