Fronto-tectal white matter connectivity mediates facilitatory effects of non-invasive neurostimulation on visual detection.
Fronto-tectal white matter connectivity mediates facilitatory effects of non-invasive neurostimulation on visual detection.
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DOI：
10.1016/j.neuroimage.2013.05.083
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发表时间：
2013-11-15
期刊：
影响因子：
5.7
通讯作者：
Valero-Cabré A
中科院分区：
文献类型：
--
作者：
Quentin R;Chanes L;Migliaccio R;Valabrègue R;Valero-Cabré A
最近已经通过非侵入性神经刺激在人类中证明了前目标FEF活动调节阈值周围刺激的视觉检测的因果能力。然而，尽管这些类型的技术的网络分布的影响，白色物质（WM）束和遥远的视觉节点，有助于这种行为的影响仍然未知。我们在此使用了来自一组健康人类受试者的个体数据，这些受试者在右额眼区（FEF）接受了主动或假经颅磁刺激（TMS）的时间锁定脉冲，并经历了视觉检测灵敏度的增加。然后，我们研究了视觉调制的个体间差异可能依赖于连接目标区域与视觉注意行为相关的其他区域的WM模式的程度。我们报告的概率之间的连接在右额顶盖通路（FEF上丘）和调制的视觉灵敏度在检测任务的统计学显着的相关性。我们的研究结果支持了这一途径和上级丘在人类额叶区域的视觉表现的调解的潜在贡献。此外，我们还展示了TMS/DTI相关方法有助于消除特定长程通路的歧义的能力，这些通路驱动全网络神经刺激对行为的影响，并预测它们在指导更有效地使用局灶性神经刺激方面的未来作用。
The causal ability of pre-target FEF activity to modulate visual detection for perithreshold stimuli has been recently demonstrated in humans by means of non-invasive neurostimulation. Yet in spite of the network-distributed effects of these type of techniques, the white matter (WM) tracts and distant visual nodes contributing to such behavioral impact remain unknown. We hereby used individual data from a group of healthy human subjects, who received time-locked pulses of active or sham Transcranial Magnetic Stimulation (TMS) to the right Frontal Eye Field (FEF) region, and experienced increases in visual detection sensitivity. We then studied the extent to which interindividual differences in visual modulation might be dependent on the WM patterns linking the targeted area to other regions relevant for visuo-attentional behaviors. We report a statistically significant correlation between the probability of connection in a right fronto-tectal pathway (FEF-Superior Colliculus) and the modulation of visual sensitivity during a detection task. Our findings support the potential contribution of this pathway and the superior colliculus in the mediation of visual performance from frontal regions in humans. Furthermore, we also show the ability of a TMS/DTI correlational approach to contribute to the disambiguation of the specific long-range pathways driving network-wide neurostimulatory effects on behavior, anticipating their future role in guiding a more efficient use of focal neurostimulation.
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影响因子：
3.2
作者：
Grosbras, MH;Paus, T
通讯作者：
Paus, T
影响因子：
1.8
作者：
Carrasco, M;Penpeci-Talgar, C;Eckstein, M
通讯作者：
Eckstein, M
DOI：
10.1016/j.jmr.2011.09.022
发表时间：
1996-06-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
Basser, PJ;Pierpaoli, C
通讯作者：
Pierpaoli, C
影响因子：
3.7
作者：
Groppe DM;Urbach TP;Kutas M
通讯作者：
Kutas M
影响因子：
5.7
作者：
De Lucia, M.;Parker, G. J. M.;Walsh, V.
通讯作者：
Walsh, V.