Therapeutics and Vaccines: Strengthening Our Fight Against the Global Pandemic COVID-19.
Therapeutics and Vaccines: Strengthening Our Fight Against the Global Pandemic COVID-19.
复制标题
治疗和疫苗：加强我们对全球大流行COVID-19的斗争。
DOI：
10.1007/s00284-020-02310-x
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发表时间：
2021-03
影响因子：
2.6
通讯作者：
Mukherjee O
中科院分区：
文献类型：
--
作者：
Bhattacharjee A;Saha M;Halder A;Debnath A;Mukherjee O
新发现的2019新型冠状病毒（SARS-CoV-2）已成为全球公共卫生问题，对人类健康和经济构成重大威胁，并在全球生活的各个领域造成前所未有的危机。在过去几年中，新的SARS-CoV基因型的出现指出了现有疫苗和抗病毒药物的有限效力，限制了全球对COVID-19爆发的反应，主要是监测/遏制。治疗制度和新的潜在治疗和疫苗战略具有高度优先地位。几种候选物在各种体外和体内模型中显示出有希望的结果。此外，临床试验正在进行中，以测试在各种体内研究中显示出有希望的结果的可想象的疗法。不幸的是，在科学范围内提供的资料很少，无法详细说明防治这一流行病的各种战略，特别是分子目标。这篇综述文章总结和强调了正在进行的进展和方法，正在进行的地球仪在设计疫苗和新的治疗方法，特别是参考以前的知识，从其他病毒感染，如早期的SARS和MERS-CoV。详细的知识可能会为抗击此次COVID-19大流行以及预防未来类似致命疫情铺平道路。
The newly identified 2019 novel coronavirus (SARS-CoV-2) has become a public health concern globally posing a significant threat to human health and economy and creating an unprecedented crisis in all spheres of the global life. Emergence of new genotypes of SARS-CoV during the last few years has pointed out the limited efficacy of available vaccines and antivirals, constraining the global response to the COVID-19 outburst to largely monitoring/containment. There is high priority for treatment regimes and new potential therapeutic and vaccine strategies. Several candidates have shown promising outcomes in various in vitro and in vivo models. In addition, clinical trials are in progress to test conceivable therapies showing promising outcomes in various in vivo studies. Unfortunately, very little information is available in the scientific scope which offers details to the diverse strategies being targeted to fight the pandemic, particularly with respect to the molecular targets. This review article summarizes and highlights the ongoing advances and approaches that are being carried out across the globe in designing vaccines and novel therapeutics, with particular reference to the previous knowledge gained from other viral infections like with the earlier SARS and MERS-CoV. A detailed knowledge may pave the way to combat this pandemic COVID-19 as well as prevent similar deadly epidemics in future.
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DOI：
10.1038/nrmicro.2016.81
发表时间：
2016-08
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
de Wit E;van Doremalen N;Falzarano D;Munster VJ
通讯作者：
Munster VJ
影响因子：
7.6
作者：
Brown, Ariane J.;Won, John J.;Sheahan, Timothy P.
通讯作者：
Sheahan, Timothy P.
影响因子：
3.7
作者：
Elshabrawy HA;Coughlin MM;Baker SC;Prabhakar BS
通讯作者：
Prabhakar BS
影响因子：
2.5
作者：
Arabi YM;Alothman A;Balkhy HH;Al-Dawood A;AlJohani S;Al Harbi S;Kojan S;Al Jeraisy M;Deeb AM;Assiri AM;Al-Hameed F;AlSaedi A;Mandourah Y;Almekhlafi GA;Sherbeeni NM;Elzein FE;Memon J;Taha Y;Almotairi A;Maghrabi KA;Qushmaq I;Al Bshabshe A;Kharaba A;Shalhoub S;Jose J;Fowler RA;Hayden FG;Hussein MA;And the MIRACLE trial group
通讯作者：
And the MIRACLE trial group
影响因子：
7.6
作者：
Caly, Leon;Druce, Julian D;Wagstaff, Kylie M
通讯作者：
Wagstaff, Kylie M