Voxel-Based Morphometry in Individuals at Genetic High Risk for Schizophrenia and Patients with Schizophrenia during Their First Episode of Psychosis.
Voxel-Based Morphometry in Individuals at Genetic High Risk for Schizophrenia and Patients with Schizophrenia during Their First Episode of Psychosis.
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DOI：
10.1371/journal.pone.0163749
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Wang F
中科院分区：
文献类型：
--
作者：
Chang M;Womer FY;Bai C;Zhou Q;Wei S;Jiang X;Geng H;Zhou Y;Tang Y;Wang F
了解精神分裂症易感期和早期疾病状态的形态学变化，有助于进一步了解精神疾病的发展。采用基于全脑体素的形态测定法，对60例首次精神病发作时的SZ患者（FE-SZ）、31例SZ遗传高风险个体（GHR-SZ）和71例健康对照进行灰质（GM）区域差异鉴定。三组患者的前额叶、顶叶、颞叶、海马、枕叶、小脑等区域差异均有统计学意义（p<0.05，校正后）。与HC组相比，FE-SZ组小脑、海马、梭状回、舌回、边缘上回、颞上回、中下回等区域GM体积显著降低，额叶中回和额叶下盖回GM体积显著增加（p<0.05）。与HC组相比，GHR-SZ组大鼠小脑、梭状回、额中回、额下盖回和颞上、中、下回的GM体积显著减少（p<0.05），而GHR-SZ组大鼠小脑、梭状回、额前回、额下盖回的GM体积显著增加（p<0.05）。与GHR-SZ组相比，FE-SZ组小脑、梭状回、边缘上回、颞上回、中下回等区域GM体积显著减少（p<0.05）。本研究结果提示多感觉统合参与了SZ的发育和病理生理。此外，观察到的差异模式提示了SZ疾病、脆弱性和复原力的可能指标。
Understanding morphologic changes in vulnerable and early disease state of schizophrenia (SZ) may provide further insight into the development of psychosis. Whole brain voxel-based morphometry was performed to identify gray matter (GM) regional differences in 60 individuals with SZ during their first psychotic episode (FE-SZ), 31 individuals at genetic high risk for SZ (GHR-SZ) individuals, and 71 healthy controls. Significant differences were found in several regions including the prefrontal cortex, parietal lobe, temporal lobe, hippocampus, occipital lobe, and cerebellum among the three groups (p<0.05, corrected). Compared to the HC group, the FE-SZ group had significantly decreased GM volumes in several regions including the cerebellum, hippocampus, fusiform gyrus, lingual gyrus, supramarginal gyrus, and superior, middle, and inferior temporal gyri and significantly increased GM volumes in the middle frontal gyrus and inferior operculum frontal gyrus (p<0.05). The GHR-SZ group had significant decreases in GM volumes in the supramaginal gyrus, precentral gyrus, and rolandic operculum and significant increases in GM volumes in the cerebellum, fusiform gyrus, middle frontal gyrus, inferior operculum frontal gyrus, and superior, middle, and inferior temporal gyri when compared to the HC group (p<0.05). Compared to the GHR-SZ group, the FE-SZ group had significant decreases in GM volumes in several regions including the cerebellum, fusiform gyrus, supramarginal gyrus, and superior, middle, and inferior temporal gyri (p<0.05). The findings herein implicate the involvement of multisensory integration in SZ development and pathophysiology. Additionally, the patterns of observed differences suggest possible indicators of disease, vulnerability, and resiliency in SZ.
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影响因子：
30.8
作者：
Ripke, Stephan;O'Dushlaine, Colm;Chambert, Kimberly;Moran, Jennifer L.;Kaehler, Anna K.;Akterin, Susanne;Bergen, Sarah E.;Collins, Ann L.;Crowley, James J.;Fromer, Menachem;Kim, Yunjung;Lee, Sang Hong;Magnusson, Patrik K. E.;Sanchez, Nick;Stahl, Eli A.;Williams, Stephanie;Wray, Naomi R.;Xia, Kai;Bettella, Francesco;Borglum, Anders D.;Bulik-Sullivan, Brendan K.;Cormican, Paul;Craddock, Nick;de Leeuw, Christiaan;Durmishi, Naser;Gill, Michael;Golimbet, Vera;Hamshere, Marian L.;Holmans, Peter;Hougaard, David M.;Kendler, Kenneth S.;Lin, Kuang;Morris, Derek W.;Mors, Ole;Mortensen, Preben B.;Neale, Benjamin M.;O'Neill, Francis A.;Owen, Michael J.;Milovancevic, Milica Pejovic;Posthuma, Danielle;Powell, John;Richards, Alexander L.;Riley, Brien P.;Ruderfer, Douglas;Rujescu, Dan;Sigurdsson, Engilbert;Silagadze, Teimuraz;Smit, August B.;Stefansson, Hreinn;Steinberg, Stacy;Suvisaari, Jaana;Tosato, Sarah;Verhage, Matthijs;Walters, James T.;Bramon, Elvira;Corvin, Aiden P.;O'Donovan, Michael C.;Stefansson, Kari;Scolnick, Edward;Purcell, Shaun;McCarroll, Steven A.;Sklar, Pamela;Hultman, Christina M.;Sullivan, Patrick F.
通讯作者：
Sullivan, Patrick F.
影响因子：
6.6
作者：
Gong Q;Dazzan P;Scarpazza C;Kasai K;Hu X;Marques TR;Iwashiro N;Huang X;Murray RM;Koike S;David AS;Yamasue H;Lui S;Mechelli A
通讯作者：
Mechelli A
影响因子：
64.8
作者：
Stefansson, Hreinn;Ophoff, Roel A.;Steinberg, Stacy;Andreassen, Ole A.;Cichon, Sven;Rujescu, Dan;Werge, Thomas;Pietilainen, Olli P. H.;Mors, Ole;Mortensen, Preben B.;Sigurdsson, Engilbert;Gustafsson, Omar;Nyegaard, Mette;Tuulio-Henriksson, Annamari;Ingason, Andres;Hansen, Thomas;Suvisaari, Jaana;Lonnqvist, Jouko;Paunio, Tiina;Borglum, Anders D.;Hartmann, Annette;Fink-Jensen, Anders;Nordentoft, Merete;Hougaard, David;Norgaard-Pedersen, Bent;Bottcher, Yvonne;Olesen, Jes;Breuer, Rene;Moeller, Hans-Jurgen;Giegling, Ina;Rasmussen, Henrik B.;Timm, Sally;Mattheisen, Manuel;Bitter, Istvan;Rethelyi, Janos M.;Magnusdottir, Brynja B.;Sigmundsson, Thordur;Olason, Pall;Mason, Gisli;Gulcher, Jeffrey R.;Haraldsson, Magnus;Fossdal, Ragnheidur;Thorgeirsson, Thorgeir E.;Thorsteinsdottir, Unnur;Ruggeri, Mirella;Tosato, Sarah;Franke, Barbara;Strengman, Eric;Kiemeney, Lambertus A.;Melle, Ingrid;Djurovic, Srdjan;Abramova, Lilia;Kaleda, Vasily;Sanjuan, Julio;de Frutos, Rosa;Bramon, Elvira;Vassos, Evangelos;Fraser, Gillian;Ettinger, Ulrich;Picchioni, Marco;Walker, Nicholas;Toulopoulou, Timi;Need, Anna C.;Ge, Dongliang;Yoon, Joeng Lim;Shianna, Kevin V.;Freimer, Nelson B.;Cantor, Rita M.;Murray, Robin;Kong, Augustine;Golimbet, Vera;Carracedo, Angel;Arango, Celso;Costas, Javier;Joensson, Erik G.;Terenius, Lars;Agartz, Ingrid;Petursson, Hannes;Nothen, Markus M.;Rietschel, Marcella;Matthews, Paul M.;Muglia, Pierandrea;Peltonen, Leena;St Clair, David;Goldstein, David B.;Stefansson, Kari;Collier, David A.
通讯作者：
Collier, David A.
影响因子：
3.7
作者：
Kent, Jerillyn S.;Hong, S. Lee;Hetrick, William P.
通讯作者：
Hetrick, William P.
影响因子：
4.1
作者：
Chang, Edward F.;Raygor, Kunal P.;Berger, Mitchel S.
通讯作者：
Berger, Mitchel S.