Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila
Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila
复制标题
来自 Plectreurys 蜘蛛毒液的神经毒素是果蝇中有效的突触前阻滞剂
作者：
W. Branton;L. Kolton;Y. Jan;L. Jan
突触传递中突触前事件的研究可能会通过使用特定的配体的功能组件的递质释放机制，并通过使用遗传学。为此目的，已经从Plectreurys spider venom（PLTX）中鉴定并纯化了影响果蝇神经肌肉传递的神经毒素。一类毒素可能通过阻断钙离子进入或作用于其他密切相关的过程，导致不可逆的突触前阻滞。这些毒素已被高度纯化，并且是分子量约7kDa的肽。它们在纳摩尔浓度下特异性地阻断递质释放，并可能在进一步的生物化学研究中有用。
Studies of presynaptic events in synaptic transmission may be facilitated through the use of specific ligands for functional components of the transmitter release mechanism and through the use of genetics. For this purpose, neurotoxins that affect neuromuscular transmission in Drosophila have been identified and purified from Plectreurys spider venom (PLTX). One class of toxins causes irreversible presynaptic block, probably by blocking calcium entry or by acting on other closely associated processes. These toxins have been highly purified and are peptides of about 7 kDa in molecular weight. They specifically block transmitter release at nanomolar concentrations and may be useful in further biochemical studies.
从蜘蛛 Hololena curta 的毒液中鉴定和纯化不可逆的突触前神经毒素。
DOI：
10.1073/pnas.84.10.3506
发表时间：
1987
影响因子：
11.1
作者：
Bowers,CW;Phillips,HS;Lee,P;Jan,YN;Jan,LY
通讯作者：
Jan,LY
影响因子：
56.9
作者：
WU, CF;GANETZKY, B;LIU, AX
通讯作者：
LIU, AX
电压调节钠通道分子。
影响因子：
18.2
作者：
Agnew,WS
通讯作者：
Agnew,WS