Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect.
Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect.
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DOI：
10.1016/j.omto.2020.10.003
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发表时间：
2020-12-16
期刊：
影响因子：
--
通讯作者：
Hamblin MR
中科院分区：
文献类型：
--
作者：
Mirzaei H;Hamblin MR
“瓦尔堡效应”描述了葡萄糖代谢从氧化磷酸化向有氧糖酵解的重新编程，它是癌细胞的标志之一。有几个因素可能参与这一过程，但在这篇综述中，非编码RNA（ncRNA）的作用在几种类型的人类癌症中被强调。ncRNA，包括microRNA、长链非编码RNA和环状RNA，都可以影响代谢酶和转录因子以促进糖酵解和调节葡萄糖代谢，从而促进肿瘤的进展。特别是，5′-AMP活化蛋白激酶（AMPK）和磷脂酰肌醇3-激酶（PI 3 K）/AKT/哺乳动物雷帕霉素靶蛋白（mTOR）通路与ncRNA的改变相关。更好地理解ncRNA在瓦尔堡效应中的作用可能最终导致抑制癌症的新治疗方法。许多ncRNA参与了糖酵解的转换，从而增加了肿瘤的整体侵袭性。进一步研究ncRNA的机制和功能不仅可以发现其他预后生物标志物，而且还有助于开发新的治疗方法。
The “Warburg effect” describes the reprogramming of glucose metabolism away from oxidative phosphorylation toward aerobic glycolysis, and it is one of the hallmarks of cancer cells. Several factors can be involved in this process, but in this review, the roles of non-coding RNAs (ncRNAs) are highlighted in several types of human cancer. ncRNAs, including microRNAs, long non-coding RNAs, and circular RNAs, can all affect metabolic enzymes and transcription factors to promote glycolysis and modulate glucose metabolism to enhance the progression of tumors. In particular, the 5′-AMP-activated protein kinase (AMPK) and the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathways are associated with alterations in ncRNAs. A better understanding of the roles of ncRNAs in the Warburg effect could ultimately lead to new therapeutic approaches for suppressing cancer. Many ncRNAs have been implicated in the switch to glycolysis, thus increasing the overall aggressiveness of the tumor. Not only could further investigation into the mechanisms and functions of ncRNAs allow the discovery of additional prognostic biomarkers, but it could also be beneficial for the development of novel therapeutic approaches.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
29
作者：
Akerman I;Tu Z;Beucher A;Rolando DMY;Sauty-Colace C;Benazra M;Nakic N;Yang J;Wang H;Pasquali L;Moran I;Garcia-Hurtado J;Castro N;Gonzalez-Franco R;Stewart AF;Bonner C;Piemonti L;Berney T;Groop L;Kerr-Conte J;Pattou F;Argmann C;Schadt E;Ravassard P;Ferrer J
通讯作者：
Ferrer J
影响因子：
2.3
作者：
Chen H;He J;Lanzafame R;Stadler I;Hamidi HE;Liu H;Celli J;Hamblin MR;Huang Y;Oakley E;Shafirstein G;Chung HK;Wu ST;Dong Y
通讯作者：
Dong Y
影响因子：
11.2
作者：
Ahmad A;Aboukameel A;Kong D;Wang Z;Sethi S;Chen W;Sarkar FH;Raz A
通讯作者：
Raz A
DOI：
10.1073/pnas.0800121105
发表时间：
2008-04-01
影响因子：
11.1
作者：
Calin, George A.;Cimmino, Amelia;Croce, Carlo M.
通讯作者：
Croce, Carlo M.