Quantum dot light emitting devices for photomedical applications.
Quantum dot light emitting devices for photomedical applications.
复制标题
用于光学应用的量子点发射器件。
DOI：
10.1002/jsid.543
复制
发表时间：
2017-03
影响因子：
2.3
通讯作者：
Dong Y
中科院分区：
文献类型：
--
作者：
Chen H;He J;Lanzafame R;Stadler I;Hamidi HE;Liu H;Celli J;Hamblin MR;Huang Y;Oakley E;Shafirstein G;Chung HK;Wu ST;Dong Y
虽然OLED一直在努力寻找一个利基照明应用，可以充分利用其独特的形状因素，薄，灵活，重量轻，均匀的大面积灯具，光医学研究人员一直在寻找低成本，有效的照明设备，这种形状因素，可以促进广泛的临床应用的光动力治疗（PDT）或光生物调节（PBM）。尽管现有的具有荧光或磷光发射体的OLED无法在光医学的正确波长窗口处实现所需的高功率密度，但最近开发的超亮和高效的深红色量子点发光器件（QLED）可以很好地适应这个利基市场。在这里，我们首次报告了体外研究，以证明这种基于QLED的光医学方法可以增加PBM控制系统的细胞代谢，并有效地杀死PDT的癌细胞。开发波长特定的，灵活的QLED的两个关键的光医学领域（伤口修复和癌症治疗）的前景将与其潜在的影响总结。这项工作有望产生灵活的基于QLED的光源，使包括PDT和PBM在内的光医学策略能够广泛使用和临床接受。
While OLEDs have struggled to find a niche lighting application that can fully take advantage of their unique form factors as thin, flexible, lightweight and uniformly large-area luminaire, photomedical researchers have been in search of low-cost, effective illumination devices with such form factors that could facilitate widespread clinical applications of photodynamic therapy (PDT) or photobiomodulation (PBM). Although existing OLEDs with either fluorescent or phosphorescent emitters cannot achieve the required high power density at the right wavelength windows for photomedicine, the recently developed ultrabright and efficient deep red quantum dot light emitting devices (QLEDs) can nicely fit into this niche. Here, we report for the first time the in-vitro study to demonstrate that this QLED-based photomedical approach could increase cell metabolism over control systems for PBM and kill cancerous cells efficiently for PDT. The perspective of developing wavelength-specific, flexible QLEDs for two critical photomedical fields (wound repair and cancer treatment) will be presented with their potential impacts summarized. The work promises to generate flexible QLED-based light sources that could enable the widespread use and clinical acceptance of photomedical strategies including PDT and PBM.
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DOI：
10.1158/1078-0432.ccr-13-1735
发表时间：
2013-12-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Rigual N;Shafirstein G;Cooper MT;Baumann H;Bellnier DA;Sunar U;Tracy EC;Rohrbach DJ;Wilding G;Tan W;Sullivan M;Merzianu M;Henderson BW
通讯作者：
Henderson BW
DOI：
10.1002/hed.24003
发表时间：
2016-04
影响因子：
2.9
作者：
Shafirstein, Gal;Rigual, Nestor R.;Arshad, Hassan;Cooper, Michele T.;Bellnier, David A.;Wilding, Gregory;Tan, Wei;Merzianu, Mihai;Henderson, Barbara W.
通讯作者：
Henderson, Barbara W.
影响因子：
6.4
作者：
Chen, Chin-Hsien;Hsu, Lun-Chia;Cheng, Chien-Hong
通讯作者：
Cheng, Chien-Hong
影响因子：
--
作者：
Shafirstein, Gal;Friedman, Adva;Suen, James Y.
通讯作者：
Suen, James Y.
DOI：
10.1016/j.wjorl.2016.05.011
发表时间：
2016-06
期刊：
World journal of otorhinolaryngology - head and neck surgery
影响因子：
--
作者：
Mimikos C;Shafirstein G;Arshad H
通讯作者：
Arshad H