Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment.

Oxidative Stress in Brain in Amnestic Mild Cognitive Impairment.
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DOI:
10.3390/antiox12020462
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发表时间:
2023-02-11
期刊:
Antioxidants (Basel, Switzerland)
影响因子:
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通讯作者:
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其他
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遗忘型轻度认知障碍(MCI)可以说是阿尔茨海默病(AD)的最早临床阶段,其特征是日常生活活动正常,但有记忆问题,但没有痴呆。氧化应激,随之而来的受损的关键蛋白质和脂质,是突出的,即使在这种早期状态的AD。这篇综述文章概述了MCI中的氧化应激,以及这如何解释神经元丢失和减缓AD进展的潜在治疗策略。
Amnestic mild cognitive impairment (MCI), arguably the earliest clinical stage of Alzheimer disease (AD), is characterized by normal activities of daily living but with memory issues but no dementia. Oxidative stress, with consequent damaged key proteins and lipids, are prominent even in this early state of AD. This review article outlines oxidative stress in MCI and how this can account for neuronal loss and potential therapeutic strategies to slow progression to AD.
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