Considerations for crossover design in clinical study.
Considerations for crossover design in clinical study.
复制标题
临床研究中的跨界设计的考虑。
DOI：
10.4097/kja.21165
复制
发表时间：
2021-08
影响因子：
2.9
通讯作者：
In J
中科院分区：
文献类型：
--
作者：
Lim CY;In J
本文介绍了临床研究中经常使用的交叉设计，其优点是在一个研究对象内比较治疗效果。特别指出了临床上广泛使用的两周期、两序列交叉设计（2 × 2或AB/BA交叉设计）的优缺点，并介绍了分析所需的要素。本文解释了交叉设计中的结转效应、阶段效应、顺序效应和阶段与治疗的相互作用，并结合实例数据检查了SAS的分析命令沿着。使用一般线性模型确认残留效应后，使用线性混合效应模型分析治疗效应。
This article introduces a crossover design that is often used in clinical studies, with the advantage of comparing treatment effects within one study subject. In particular, the advantages and disadvantages of the two-period, two-sequence crossover design (2 × 2 or AB/BA crossover design), which is widely used in clinical practice, are identified, and the elements necessary for analysis are introduced. This article explains the carryover effect, period effect, sequence effect, and period-by-treatment interaction in a crossover design and examines the analysis commands of SAS along with example data. After confirming the carryover effect using a general linear model, the treatment effect is analyzed using a linear mixed effect model.
影响因子：
2.9
作者：
Lim, Chi-Yeon;In, Junyong
通讯作者：
In, Junyong
影响因子：
2
作者：
SENN, SJ;AUCLAIR, P
通讯作者：
AUCLAIR, P