Human Case Infected With Babesia venatorum: A 5-Year Follow-Up Study
Human Case Infected With Babesia venatorum: A 5-Year Follow-Up Study
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人类感染巴贝斯虫的病例：一项 5 年跟踪研究
DOI：
10.1093/ofid/ofaa062
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发表时间：
2020-02
影响因子：
4.2
通讯作者：
Cao Wuchun
中科院分区：
文献类型：
--
作者：
Zhao Lin;Jiang Ruiruo;Jia Na;Ning Nianzhi;Zheng Yuanchun;Huo Qiubo;Sun Yi;Yuan Tingting;Jiang Baogui;Li Tao;Liu Hongbo;Liu Xiong;Chu Yanli;Wei Ran;Bian Cai;Wang Hong;Song Juliang;Wang Hui;Jiang Jiafu;Cao Wuchun
摘要背景人类巴贝斯虫病是由巴贝斯虫引起的一种常见人畜共患病，在全世界范围内引起了越来越多的关注。巴贝斯虫感染的自然过程以及人类免疫系统在巴贝斯虫感染过程中如何变化尚不清楚。方法对1例猎性巴贝斯虫感染者进行5年随访。该患者免疫完好，未接受标准治疗。临床数据从医疗记录中获得。不同时间点进行微生物学检测、核糖核酸（RNA）序列、血清细胞因子和趋化因子检测。结果根据患者蜱虫叮咬史、临床表现及微生物学检测阳性结果，确诊为B venatorum感染。患者的寄生虫血症持续了约2个月。随着流感样症状加重，RNA和蛋白质中大多数细胞因子和趋化因子的水平逐渐升高，并在发热时达到峰值；在巴贝虫寄生虫被清除的同时，它们的浓度下降到基线。结论 在免疫完整的个体中，猎性巴贝斯虫感染可呈轻度自限性病程。大多数细胞因子和趋化因子的自然变化表现出非常相似的趋势，这与血液寄生虫血症和临床表现相关。涉及多种炎症细胞因子的细胞因子谱可能是巴贝虫感染的良好指标。
Abstract Background Human babesiosis is a common zoonosis caused by Babesia and is attracting an increasing concern worldwide. The natural course of babesiosis infection and how the human immune system changes during the course of babesiosis infection are not clear. Methods We followed up 1 case infected with Babesia venatorum for 5 years. The patient was immune-intact and received no standard treatment. Clinical data were obtained from medical records. Microbiological tests, ribonucleic acid (RNA) sequence, and serum cytokines and chemokines were detected at different time points. Results The patient was confirmed as B venatorum infection based on his tick-bite history, clinical manifestations, and positive results of microbiological tests. The parasitemia of the patient persisted for approximately 2 months. With flu-like symptoms aggravating, most cytokines and chemokines in RNA and protein levels increased progressively and reached the peak when fever occurred; and their concentrations decreased to baseline during the same time as clearance of babesia parasites. Conclusions Babesia venatorum infection could take a mild self-limited course in immune-intact individuals. The natural changes of most cytokines and chemokines demonstrated very similar trends, which correlated with blood parasitemia and clinical manifestations. Cytokine profiles involving multiple inflammatory cytokines might be a good indicator of babesia infection.
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影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
影响因子：
11.8
作者：
Boustani, MR;Gelfand, JA
通讯作者：
Gelfand, JA
影响因子：
4.4
作者：
Vannier, Edouard G.;Diuk-Wasser, Maria A.;Krause, Peter J.
通讯作者：
Krause, Peter J.
影响因子：
36.8
作者：
M. Homer;I. Aguilar-Delfín;S. Telford;P. Krause;D. Persing
通讯作者：
M. Homer;I. Aguilar-Delfín;S. Telford;P. Krause;D. Persing
DOI：
10.1016/s1473-3099(04)00970-3
发表时间：
2004-04-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Piccaluga, Pier Paolo;Poletti, Giovanni;Gherlinzoni, Filippo
通讯作者：
Gherlinzoni, Filippo