Metabolic reprogramming and epigenetic modifications on the path to cancer.
Metabolic reprogramming and epigenetic modifications on the path to cancer.
复制标题
癌症路径中的代谢重编程和表观遗传修饰。
DOI：
10.1007/s13238-021-00846-7
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发表时间：
2022-12
期刊：
影响因子：
21.1
通讯作者：
Gao, Ping
中科院分区：
文献类型：
--
作者：
Sun, Linchong;Zhang, Huafeng;Gao, Ping
代谢重新布线和表观遗传重塑密切相关，相互调节，是众所周知的癌症标志之一。最近的证据表明，许多代谢物作为底物或辅因子的染色质修饰酶的易位或空间区域化的酶或代谢物的结果。据报道，各种代谢改变和表观遗传修饰也在某些情况下驱动免疫逃逸或阻碍免疫监视，在肿瘤进展中发挥重要作用。在这篇综述中，我们关注肿瘤细胞和免疫细胞的代谢重编程如何重塑表观遗传改变，特别是组蛋白和DNA的乙酰化和甲基化。我们还讨论了其他著名的代谢修饰，如琥珀酰化，羟基丁酰化和乳酸化，并更新目前的进展代谢和表观遗传修饰为基础的癌症治疗前景。在线版本包含补充材料，可在（10.1007/s13238-021-00846-7）中获得，包含授权用户可用的补充材料。
Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally regulate each other, are among the well-known cancer hallmarks. Recent evidence suggests that many metabolites serve as substrates or cofactors of chromatin-modifying enzymes as a consequence of the translocation or spatial regionalization of enzymes or metabolites. Various metabolic alterations and epigenetic modifications also reportedly drive immune escape or impede immunosurveillance within certain contexts, playing important roles in tumor progression. In this review, we focus on how metabolic reprogramming of tumor cells and immune cells reshapes epigenetic alterations, in particular the acetylation and methylation of histone proteins and DNA. We also discuss other eminent metabolic modifications such as, succinylation, hydroxybutyrylation, and lactylation, and update the current advances in metabolism- and epigenetic modification-based therapeutic prospects in cancer. The online version contains supplementary material available at (10.1007/s13238-021-00846-7) contains supplementary material, which is available to authorized users.
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DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
DOI：
10.1126/science.aaw9872
发表时间：
2020-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badgley MA;Kremer DM;Maurer HC;DelGiorno KE;Lee HJ;Purohit V;Sagalovskiy IR;Ma A;Kapilian J;Firl CEM;Decker AR;Sastra SA;Palermo CF;Andrade LR;Sajjakulnukit P;Zhang L;Tolstyka ZP;Hirschhorn T;Lamb C;Liu T;Gu W;Seeley ES;Stone E;Georgiou G;Manor U;Iuga A;Wahl GM;Stockwell BR;Lyssiotis CA;Olive KP
通讯作者：
Olive KP
DOI：
10.1083/jcb.153.4.865
发表时间：
2001-05-14
期刊：
The Journal of cell biology
影响因子：
--
作者：
Adams RR;Maiato H;Earnshaw WC;Carmena M
通讯作者：
Carmena M
影响因子：
6.6
作者：
Alvarez-Nuñez, F;Bussaglia, E;Matias-Guju, X
通讯作者：
Matias-Guju, X
影响因子：
51.1
作者：
Bayley, Jean-Pierre;Kunst, Henricus P. M.;Robledo, Mercedes
通讯作者：
Robledo, Mercedes