Iron-responsive riboswitches.
Iron-responsive riboswitches.
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DOI：
10.1016/j.cbpa.2022.102135
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发表时间：
2022-06
影响因子：
7.8
通讯作者：
中科院分区：
文献类型：
--
作者：
所有细胞都必须管理必需金属离子的不足、充足和过剩。虽然铁是生物学中最重要的金属之一已有数十亿年的历史，但细菌科普高细胞内铁浓度的机制直到最近才受到关注。最近的研究表明，最初被认为对CoII和NiII过量有特异性反应的RNA核糖开关（czcD或“NiCo”）更可能是重要的人类肠道细菌和病原体中FeII水平的选择性调节剂。我们讨论了铁响应核糖开关的表征中遇到的挑战和争议，我们建议在响应铁过载的生理作用，也许在厌氧。最后，我们把这些核糖开关的背景下，更好地理解基于蛋白质的金属离子调节机制，提出核糖开关介导的机制可能是特别重要的，在调节运输最弱的结合生物二价金属离子，镁II，锰II，铁II。
All cells must manage deficiency, sufficiency, and excess of essential metal ions. Although iron has been one of most important metals in biology for billions of years, the mechanisms by which bacteria cope with high intracellular iron concentrations are only recently coming into focus. Recent work has suggested that an RNA riboswitch (czcD or “NiCo”), originally thought to respond specifically to CoII and NiII excess, is more likely a selective regulator of FeII levels in important human gut bacteria and pathogens. We discuss the challenges and controversies encountered in the characterization of iron-responsive riboswitches, and we suggest a physiological role in responding to iron overload, perhaps during anaerobiosis. Finally, we place these riboswitches in the context of the better understood mechanisms of protein-based metal ion regulation, proposing that riboswitch-mediated mechanisms may be particularly important in regulating transport of the weakest-binding biological divalent metal ions, MgII, MnII, and FeII.
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影响因子：
7.8
作者：
Foster AW;Young TR;Chivers PT;Robinson NJ
通讯作者：
Robinson NJ
DOI：
10.1073/pnas.88.10.4080
发表时间：
1991-05-01
影响因子：
11.1
作者：
BRESLOW, R;HUANG, DL
通讯作者：
HUANG, DL
影响因子：
64.8
作者：
IRVING, H;WILLIAMS, RJP
通讯作者：
WILLIAMS, RJP
影响因子：
3.2
作者：
Fuangthong, M;Helmann, JD
通讯作者：
Helmann, JD
影响因子：
5.4
作者：
Dambach, Michael D.;Winkler, Wade C.
通讯作者：
Winkler, Wade C.