Elevated expression of squamous cell carcinoma antigen (SCCA) is associated with human breast carcinoma.
Elevated expression of squamous cell carcinoma antigen (SCCA) is associated with human breast carcinoma.
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DOI：
10.1371/journal.pone.0019096
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发表时间：
2011-04-19
期刊：
影响因子：
3.7
通讯作者：
Zong WX
中科院分区：
文献类型：
--
作者：
Catanzaro JM;Guerriero JL;Liu J;Ullman E;Sheshadri N;Chen JJ;Zong WX
鳞状细胞癌抗原（SCCA）属于丝氨酸蛋白酶抑制剂（Serpin）蛋白家族。SCCA表达升高已被用作宫颈癌、肺癌、头颈癌和肝癌中侵袭性鳞状细胞癌（SCC）的生物标志物。然而，SCCA在乳腺癌中的表达尚未被研究。在包含乳腺肿瘤组织（n = 1,360）和正常乳腺上皮（n = 124）的组织微阵列上进行SCCA表达的免疫组织化学分析。SCCA表达由两名不了解患者临床状况的评估者独立地按分级（0-3）评分。SCCA在I级（0.3%）、II级（2.5%）和III级（9.4%）乳腺癌中均有表达（p<0.0001）。将组织分为三个非转移性TNM阶段，I-III， SCCA阳性在I期癌症中占2.4%，II期癌症中占3.1%，III期乳腺癌中占8.6% （p = 0.0005）。正常/非肿瘤乳腺组织未见阳性染色（124例中0例）。SCCA表达与雌激素受体/孕激素受体（ER/PR）双阴性肿瘤相关（p = 0.0009）。与scca阴性患者相比，scca阳性患者的总生存期和无复发生存期均较差（p<0.0001和p<0.0001）。本研究表明SCCA与晚期和高分级人乳腺癌均相关，提示进一步探讨SCCA在乳腺癌发展和治疗中的作用是必要的。
Squamous cell carcinoma antigen (SCCA) belongs to the serine protease inhibitor (Serpin) family of proteins. Elevated expression of SCCA has been used as a biomarker for aggressive squamous cell carcinoma (SCC) in cancers of the cervix, lung, head and neck, and liver. However, SCCA expression in breast cancer has not been investigated. Immunohistochemical analysis of SCCA expression was performed on tissue microarrays containing breast tumor tissues (n = 1,360) and normal breast epithelium (n = 124). SCCA expression was scored on a tiered scale (0-3) independently by two evaluators blind to the patient's clinical status. SCCA expression was observed in Grade I (0.3%), Grade II (2.5%), and Grade III (9.4%) breast cancers (p<0.0001). Comparing tissues categorized into the three non-metastatic TNM stages, I-III, SCCA positivity was seen in 2.4% of Stage I cancers, 3.1% of Stage II cancers, and 8.6% of Stage III breast cancers (p = 0.0005). No positive staining was observed in normal/non-neoplastic breast tissue (0 out of 124). SCCA expression also correlated to estrogen receptor/progesterone receptor (ER/PR) double-negative tumors (p = 0.0009). Compared to SCCA-negative patients, SCCA-positive patients had both a worse overall survival and recurrence-free survival (p<0.0001 and p<0.0001, respectively). This study shows that SCCA is associated with both advanced stage and high grade human breast carcinoma, and suggests the necessity to further explore the role of SCCA in breast cancer development and treatment.
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影响因子：
3.8
作者：
Turashvili, Gulisa;Bouchal, Jan;Baumforth, Karl;Wei, Wenbin;Dziechciarkova, Marta;Ehrmann, Jiri;Klein, Jiri;Fridman, Eduard;Skarda, Jozef;Srovnal, Josef;Hajduch, Marian;Murray, Paul;Kolar, Zdenek
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通讯作者：
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作者：
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通讯作者：
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作者：
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通讯作者：
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影响因子：
45.3
作者：
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通讯作者：
Hortobagyi, GN