Blood Eosinophil and Neutrophil Categories Can Differentiate Adult Asthma Phenotypes.
Blood Eosinophil and Neutrophil Categories Can Differentiate Adult Asthma Phenotypes.
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血液嗜酸性粒细胞和中性粒细胞类别可以区分成人哮喘表型。
DOI：
10.1016/j.jaip.2023.01.006
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Teague,WGerald
中科院分区：
文献类型：
--
作者：
Rupani,Hitasha;Teague,WGerald
哮喘是一种异质性综合征，包括由不同类型的炎症引起的共有52种呼吸道症状的患者。认识到患者的显著炎症模式，通常称为其“内型”，在预测治疗反应、可能的合并症和肺功能降低的风险方面改善了临床实践。1新型疗法的制造商和临床研究人员56长期以来一直在进行研究，以寻找和验证识别特定炎症内型的“生物标志物”。这些努力是由生物标志物可以指导精确治疗的承诺驱动的，从而使患者免于不适合其炎症内型的治疗。迄今为止最受关注的生物标志物是血液嗜酸性粒细胞计数，其水平较高，与症状增加和61次急性加重的风险相关，对皮质类固醇和靶向62种2型细胞因子的生物制剂的反应更好。2然而，迄今为止，很少关注其他血液63粒细胞群体及其与临床特征和分子机制的关联。6566在本期《JACI in Practice》中，Flinkman等3采用一种可行的方法将203 67例成人发作的哮喘患者根据血液嗜酸性粒细胞和中性粒细胞计数分为4类，哮喘的严重程度从轻度到重度不等。血液采样在单个时间点进行，但临床特征是从一项为期12年的纵向观察性研究中收集的。71
51 Asthma is a heterogenous syndrome that includes patients that share common 52 respiratory symptoms caused by diverse patterns of inflammation. Awareness of a 53 patient’s salient pattern of inflammation, popularly termed their “endotype,” improves 54 clinical practice in a way to predict treatment response, likely comorbidities, and the risk 55 of reduced lung function. 1 Manufacturers of novel therapies and clinician-investigators 56 both have long pursued studies to find and validate “biomarkers” that recognize specific 57 inflammatory endotypes. These efforts are driven by the promise that biomarkers can 58 guide precision treatment and thereby spare patients from therapies not appropriate for 59 their inflammatory endotype. The biomarker with the most focus to date is the blood 60 eosinophil count with higher levels associated with increased symptoms and risk of 61 exacerbations and a better response to corticosteroids and biologic agents targeting 62 type-2 cytokines. 2 However, to date, there has been little focus on other blood 63 granulocyte populations and their association with clinical characteristics and molecular 64 mechanisms. 6566 In this issue of JACI in Practice, Flinkman et al 3 used a feasible approach to divide 203 67 adult-onset asthmatics, with varying severity of asthma ranging from mild to severe 68 disease, into four categories based on blood eosinophil and neutrophil counts (see 69 Figure). Blood sampling occurred at a single time point but clinical characteristics were 70 collected from a longitudinal twelve-year observational study. 71
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DOI：
10.1016/s2213-2198(21)00110-0
发表时间：
2021-03-05
期刊：
The Journal of Allergy and Clinical Immunology. in Practice
影响因子：
--
作者：
通讯作者：
--
结合肺音分析和呼出一氧化氮分数进行表型分类，以评估哮喘治疗。
DOI：
10.1016/j.alit.2017.09.004
发表时间：
2017
期刊：
Allergology international : official journal of the Japanese Society of Allergology
影响因子：
--
作者：
T. Shimoda;Y. Obase;Y. Nagasaka;S. Asai
通讯作者：
S. Asai
DOI：
10.1016/j.jaip.2022.11.025
发表时间：
2023-03-07
影响因子：
9.4
作者：
Flinkman，Ella;Vahatalo，Iida;Ilmarinen，Pinja
通讯作者：
Ilmarinen，Pinja
影响因子：
24.3
作者：
Nadif, Rachel;Siroux, Valerie;Pin, Isabelle
通讯作者：
Pin, Isabelle