Downregulated Expression of hsa_circ_0005556 in Gastric Cancer and Its Clinical Significance
Downregulated Expression of hsa_circ_0005556 in Gastric Cancer and Its Clinical Significance
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hsa_circ_0005556在胃癌中的表达下调及其临床意义
DOI：
10.1155/2019/2624586
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发表时间：
2019-11
期刊：
影响因子：
--
通讯作者：
Yan Zhilong
中科院分区：
文献类型：
--
作者：
Yang Liangwei;Yu Yu;Yu Xiuchong;Zhou Jiaming;Zhang Zhiping;Ying Shibo;Guo Junming;Yan Zhilong
背景由于缺乏理想的肿瘤标志物，胃癌（GC）预后较差。Circular RNA（circRNA）是一类与胃癌发生相关的新型非编码RNA。在我们的研究中，我们研究了hsa_circ_0005556在GC中的作用。材料与方法采用定量逆转录-聚合酶链反应（qRT-PCR）检测100例配对胃癌组织及癌旁正常组织中hsa_circ_0005556的表达。建立受试者工作特征（ROC）曲线以评价hsa_circ_0005556的诊断价值。探讨hsa_circ_0005556的表达与相应临床病理特征的关系。结果hsa_circ_0005556在胃癌组织中的表达明显低于癌旁正常组织（n = 100，p < 0.001）。hsa_circ_0005556的ROC曲线下面积（AUC）达0.773，敏感性为64%，特异性为82%。此外，其表达水平与分化（p = 0.001）、TNM分期（p = 0.013）和淋巴结转移（p = 0.039）显著相关。高hsa_circ_0005556水平的GC患者的总生存期（OS）长于低水平组（p = 0.047）。结论hsa_circ_0005556是一种潜在的胃癌生物标志物，可指导早期胃癌内镜治疗指征的判断。
Background Gastric cancer (GC) has a poor prognosis due to the lack of ideal tumor markers. Circular RNAs (circRNAs) are a novel type of noncoding RNA related to the occurrence of GC. Among our research, we investigated the role of hsa_circ_0005556 in GC. Materials and Methods The expression of hsa_circ_0005556 of 100 paired GC tissues and adjacent normal tissues was detected using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was established to evaluate the diagnostic value of hsa_circ_0005556. The correlation between the expression of hsa_circ_0005556 and corresponding clinicopathological characteristic was explored. Results hsa_circ_0005556 was significantly downregulated in GC tissues contrasted with adjacent normal tissues (n = 100, p < 0.001). The areas under the ROC curve (AUC) of hsa_circ_0005556 were up to 0.773, while 64% sensitivity and 82% specificity, respectively. Moreover, its expression levels were significantly associated with differentiation (p = 0.001), TNM stage (p = 0.013), and lymphatic metastasis (p = 0.039). GC patients of high hsa_circ_0005556 levels had a longer overall survival (OS) than those of the low group (p = 0.047). Conclusion hsa_circ_0005556 is a potential biomarker for GC, which may guide judgment of the indication of endoscopic treatment for early gastric cancer (EGC).
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DOI：
10.1007/s10120-016-0601-9
发表时间：
2017-03
期刊：
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
影响因子：
--
作者：
Sano T;Coit DG;Kim HH;Roviello F;Kassab P;Wittekind C;Yamamoto Y;Ohashi Y
通讯作者：
Ohashi Y
影响因子：
4.6
作者：
Bachmayr-Heyda A;Reiner AT;Auer K;Sukhbaatar N;Aust S;Bachleitner-Hofmann T;Mesteri I;Grunt TW;Zeillinger R;Pils D
通讯作者：
Pils D
DOI：
10.1007/s12288-016-0733-4
发表时间：
2017-09-01
影响因子：
0.9
作者：
Emamdoost, Fatemeh;Khanahmad, Hossein;Doosti, Abbas
通讯作者：
Doosti, Abbas
影响因子：
9.3
作者：
Kim, Young-Il;Kim, Young-Woo;Kook, Myeong-Cheorl
通讯作者：
Kook, Myeong-Cheorl
DOI：
10.1073/pnas.1117815109
发表时间：
2012-03-06
影响因子：
11.1
作者：
Wu, Qingfa;Wang, Ying;Ding, Shou-Wei
通讯作者：
Ding, Shou-Wei