Plasma beta-amyloid and duration of Alzheimer's disease in adults with Down syndrome.
Plasma beta-amyloid and duration of Alzheimer's disease in adults with Down syndrome.
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DOI：
10.1002/gps.2321
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发表时间：
2010-02
影响因子：
4
通讯作者：
Schupf, N.
中科院分区：
文献类型：
--
作者：
Prasher, V. P.;Sajith, S. G.;Mehta, P.;Zigman, W. B.;Schupf, N.
探讨成人唐氏综合症 (DS) 患者血浆 Aβ 肽（Aβ1-40 和 Aβ1-42）和载脂蛋白 E (APOE) 基因型水平与痴呆状态和阿尔茨海默氏病持续时间的关系。患有 DS 的成年人是从社区环境中招募的，并进行平均 6.7 年的随访。在最后一次访视时测定血浆 Aβ1-40 和 Aβ1-42 水平以及 APOE 基因型。有 83 名非痴呆参与者和 44 名患有 AD 的参与者。总体而言，DS 成人之间的血浆 Aβ1-42、Aβ1-40 水平以及 Aβ1-42/Aβ1-40 比率没有显着差异。在痴呆患者中，痴呆病程超过 4 年的参与者的 Aβ1-40 平均水平显着较低（157.0 vs. 195.3），Aβ1-42/Aβ1-40 的比率显着高于痴呆病程 4 年或以下的参与者（0.28 vs. 0.16）。这种模式在有和没有 APOE ε4 等位基因的人中通常是相似的。患有 DS 的老年人的血浆 Aβ 肽水平与 AD 持续时间之间存在关联。然而，Aβ1-42 和 Aβ1-40 测量对 AD 的预测和诊断作用仍然存在争议。 Aβ 肽水平随 AD 发病和痴呆持续时间的变化可能解释了流行病例和非痴呆个体之间缺乏差异以及 Aβ 肽水平的预测能力的变化。
To investigate the relation of plasma levels of Aβ peptides (Aβ1-40 and Aβ1-42) and Apolipoprotein E (APOE) genotype to dementia status and duration of Alzheimer’s disease in adults with Down syndrome (DS). Adults with DS were recruited from community settings and followed up for a mean period of 6.7 years. Plasma levels Aβ1-40 and Aβ1-42 and APOE genotype were determined at the last visit. There were 83 nondemented participants and 44 participants with prevalent AD. Overall, plasma levels of Aβ1-42, Aβ1-40 and the ratio Aβ1-42/Aβ1-40 did not differ significantly between the adults with DS. Among demented participants the mean level of Aβ1-40 was significantly lower (157.0 vs. 195.3) and the ratio of Aβ1-42/Aβ1-40 was significantly higher (0.28 vs. 0.16) in those with more than 4 years duration of dementia than in those with 4 or fewer years duration of dementia. This pattern was generally similar in those with and without an APOE ε4 allele. There is an association between plasma Aβ peptide levels and duration of AD in older persons with DS. The predictive and diagnostic roles of Aβ1-42 and Aβ1-40 measurements for AD, however, remain controversial. Change in Aβ peptide levels with onset of AD and with duration of dementia may account for lack of difference between prevalent cases and nondemented individuals and for variation in the predictive power of Aβ peptide levels.e
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通讯作者：
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4
作者：
Prasher, V. P.;Sajith, S. G.;Zigman, W. B.
通讯作者：
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