Exploring genetic association of insomnia with allergic disease and asthma: a bidirectional Mendelian randomization study.
Exploring genetic association of insomnia with allergic disease and asthma: a bidirectional Mendelian randomization study.
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探索失眠与过敏性疾病和哮喘的遗传关联：双向孟德尔随机研究
DOI：
10.1186/s12931-022-02009-6
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发表时间：
2022-04-07
影响因子：
5.8
通讯作者：
Li S
中科院分区：
文献类型：
--
作者：
Li R;Chen Y;Zhao A;Huang L;Long Z;Kang W;Yin Y;Tong S;Guo Y;Li S
过敏性疾病和哮喘患者中，过敏性疾病非常普遍;然而，很少有研究调查它们之间的因果关系。我们的目的是通过双向孟德尔随机化（MR）研究来探讨失眠与过敏性疾病/哮喘之间的因果关系。使用单核苷酸多态性（SNP）构建工具变量。失眠、过敏性疾病和哮喘的汇总统计数据来自四项欧洲血统的大规模全基因组关联研究（GWAS）。通过使用MR-Egger截距检验和MR多效性残差和离群值（MR-EGO）检验进行多效性分析。MR分析采用逆方差加权（IVW）、加权中位数和MR-Egger方法。基于乘性随机效应IVW方法，MR分析显示遗传预测失眠与过敏性疾病风险增加[OR = 1.054，95%可信区间（CI）= 1.031-1.078，P = 3.817 × 10-06]、哮喘风险增加[OR = 1.054，95%可信区间（CI）= 1.031-1.078，P = 3.817 × 10-06]有因果关系（OR = 1.043，95%CI = 1.010-1.077，P = 9.811 × 10-03），中重度哮喘成人哮喘（OR = 1.086，95% CI = 1.037-1.138，P = 4.922 × 10-04）。在双向分析中，我们没有发现支持反向因果关系的证据。我们的MR研究表明，遗传预测失眠是过敏性疾病和哮喘的危险因素。改善睡眠质量可能是预防过敏性疾病和哮喘的基石之一。在线版本包含补充材料，可通过10.1186/s12931-022-02009-6获得。
Insomnia is highly prevalent among patients with allergic disease and asthma; however, few studies have investigated their causal relationship. We aim to explore the causal association between insomnia and allergic disease/asthma by performing bidirectional Mendelian randomization (MR) study. Instrumental variables were constructed using single nucleotide polymorphisms (SNPs). Summary statistics for insomnia, allergic disease, and asthma were obtained from four large-scale genome-wide association studies (GWAS) of European ancestry. The pleiotropy analysis was applied by using the MR-Egger intercept test and the MR pleiotropy residual sum and outlier (MR-PRESSO) test. MR analyses were conducted by using inverse variance weighted (IVW), weighted median, and MR-Egger method. Based on the multiplicative random effects IVW method, the MR analysis showed that genetically predicted insomnia was causally associated with an increased risk of allergic disease [odds ratio (OR) = 1.054, 95% confidence interval (CI) = 1.031–1.078, P = 3.817 × 10–06], asthma (OR = 1.043, 95% CI = 1.010–1.077, P = 9.811 × 10–03), moderate-severe asthma (OR = 1.168, 95% CI = 1.069–1.277, P = 6.234 × 10–04), and adult-onset asthma (OR = 1.086, 95% CI = 1.037–1.138, P = 4.922 × 10–04). In bidirectional analyses, we did not find evidence supporting the reverse causality relations. Our MR study suggested that genetically predicted insomnia was the risk factor for allergic disease and asthma. Improving sleep quality could be one of the cornerstones in the prevention of allergic disease and asthma. The online version contains supplementary material available at 10.1186/s12931-022-02009-6.
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影响因子：
7.7
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan NA;Thompson JR
通讯作者：
Thompson JR
影响因子：
4.6
作者：
Kim DJ;Ha TW;Jung HU;Baek EJ;Lee WJ;Kim HK;Kang JO;Won S;Lim JE;Oh B
通讯作者：
Oh B
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
DOI：
10.1097/ede.0000000000000559
发表时间：
2017-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Burgess S;Bowden J;Fall T;Ingelsson E;Thompson SG
通讯作者：
Thompson SG
影响因子：
14.2
作者：
Chang, Yung-Sen;Chiang, Bor-Luen
通讯作者：
Chiang, Bor-Luen