The angiogenic inhibitor TNP-470 decreases caloric intake and weight gain in high-fat fed mice.
The angiogenic inhibitor TNP-470 decreases caloric intake and weight gain in high-fat fed mice.
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DOI：
10.1038/oby.2012.87
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发表时间：
2012-10
期刊：
影响因子：
6.9
通讯作者：
Considine, Robert V.
中科院分区：
文献类型：
--
作者：
White, Heather M.;Acton, Anthony J.;Considine, Robert V.
血管生成抑制剂TNP-470减弱高脂饮食诱导的肥胖;然而，尚不清楚该化合物如何改变能量平衡以防止体重增加。给5周龄C57 Bl/6 J小鼠喂食高脂肪饮食（45%能量来自脂肪）6.5周，并用TNP-470（20 mg/kg体重; n=7）或媒介物（盐水; n=7）处理。对照小鼠（n=8）接受标准食物和假注射。TNP-470小鼠最初体重增加，但到第5天体重显著低于高脂肪喂养（HFF）小鼠，并且与普通饲料喂养小鼠的体重没有差异，该效果维持至研究结束（28.6±0.6对比22.4±0.6和22.2±0.5g）。与HFF小鼠相比，TNP-470小鼠的体脂百分比降低，但高于普通饲料小鼠（34.0±1.5，23.9±1.5，17.0± 1.4%，P<0.05）。TNP-470处理的小鼠中的食物摄入在处理的第5天比HFF小鼠中的食物摄入少（P<0.05）（2.5±0.1 g/小鼠/天对2.8±0.1 g/小鼠/天），并且保持到研究结束。TNP-470小鼠的24小时能量消耗大于HFF或普通饲料小鼠（7.05±0.07 vs. 6.69±0.08 vs. 6.79±0.09 kcal/kg/h）（P<0.05），该效应无法通过运动能量消耗的差异来解释。尽管体重正常化，但TNP-470小鼠表现出葡萄糖耐量受损（AUC 30556±1918和29290±1584对TNP、HFF和食物喂养的24421±903，P<0.05）。总之，血管生成抑制剂TNP-470通过减少热量摄入和增加能量消耗来减弱高脂肪喂养小鼠的体重增加。
The angiogenic inhibitor TNP-470 attenuates high fat diet induced obesity; however, it is not clear how the compound alters energy balance to prevent weight gain. Five week old C57Bl/6J mice were fed high-fat diet (45% energy from fat) for 6.5 weeks and treated with TNP-470 (20 mg/kg body weight; n=7) or vehicle (saline; n=7). Control mice (n=8) received standard chow and sham injection. TNP-470 mice initially gained weight, but by day 5 body weight was significantly less than high fat fed (HFF) mice and not different from that of chow fed mice, an effect maintained to the end of the study (28.6±0.6 vs. 22.4±0.6 and 22.2±0.5g). Percent body fat was reduced in TNP-470 compared to HFF mice, but was greater than that of chow mice (34.0±1.5, 23.9±1.5, and 17.0±1.4%, P<0.05). Food intake in TNP-470 treated mice was less (P<0.05) than that in HFF mice by day 5 of treatment (2.5±0.1 vs 2.8±0.1 g/mouse/day) and remained so to the end of the study. 24 h energy expenditure was greater (P<0.05) in TNP-470 than HFF or chow mice (7.05±0.07 vs. 6.69±0.08 vs 6.79±0.09 kcal/kg/h), an effect not explained by a difference in energy expended in locomotion. Despite normalization of body weight, TNP-470 mice exhibited impaired glucose tolerance (AUC 30556±1918 and 29290±1584 vs. 24421±903 for TNP, HFF, and chow fed, P<0.05). In summary, the angiogenic inhibitor TNP-470 attenuates weight gain in high fat fed mice via a reduction in caloric intake and an increase in energy expenditure.
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影响因子：
120.1
作者：
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通讯作者：
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影响因子：
7.7
作者：
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影响因子：
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影响因子：
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DOI：
10.1111/j.1742-4658.2009.07303.x
发表时间：
2009-10
期刊：
The FEBS journal
影响因子：
--
作者：
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通讯作者：
Scherer PE