The dual role and therapeutic potential of high-mobility group box 1 in cancer.
The dual role and therapeutic potential of high-mobility group box 1 in cancer.
复制标题
高迁移率族蛋白1在癌症中的双重作用和治疗潜力
DOI：
10.18632/oncotarget.17885
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发表时间：
2017-09-08
期刊：
影响因子：
--
通讯作者：
Huang Q
中科院分区：
文献类型：
--
作者：
He SJ;Cheng J;Feng X;Yu Y;Tian L;Huang Q
高迁移率族蛋白1（HMGB1）是大多数真核细胞中丰富的蛋白质。它可以直接或间接地与多种受体结合，例如晚期糖基化终产物（RAGE）和Toll样受体（TLR）。HMGB1的生物学效应取决于其表达和亚细胞定位。在细胞核内，HMGB1参与许多DNA事件，如DNA修复、转录、端粒维持和基因组稳定性。而在细胞核外，它具有更复杂的功能，包括调节细胞增殖、自噬、炎症和免疫。在肿瘤发生发展过程中，HMGB1通过促进或抑制肿瘤生长、增殖、血管生成、侵袭和转移而被表征为促肿瘤和抗肿瘤蛋白。然而，目前关于HMGB1对肿瘤发展的积极和消极影响的知识并不明确。在这里，我们评估HMGB1在肿瘤发展中的作用，并试图调和HMGB1在致癌作用中的双重作用。此外，我们希望提出针对HMGB1，其受体或释放的当前策略，这些策略在癌症干预中显示出潜在的治疗价值。
High-mobility group box 1 (HMGB1) is an abundant protein in most eukaryocytes. It can bind to several receptors such as advanced glycation end products (RAGE) and Toll-like receptors (TLRs), in direct or indirect way. The biological effects of HMGB1 depend on its expression and subcellular location. Inside the nucleus, HMGB1 is engaged in many DNA events such as DNA repair, transcription, telomere maintenance, and genome stability. While outside the nucleus, it possesses more complicated functions, including regulating cell proliferation, autophagy, inflammation and immunity. During tumor development, HMGB1 has been characterized as both a pro- and anti-tumoral protein by either promoting or suppressing tumor growth, proliferation, angiogenesis, invasion and metastasis. However, the current knowledge concerning the positive and negative effects of HMGB1 on tumor development is not explicit. Here, we evaluate the role of HMGB1 in tumor development and attempt to reconcile the dual effects of HMGB1 in carcinogenesis. Furthermore, we would like to present current strategies targeting against HMGB1, its receptor or release, which have shown potentially therapeutic value in cancer intervention.
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