Visual Restoration after Cataract Surgery Promotes Functional and Structural Brain Recovery.
Visual Restoration after Cataract Surgery Promotes Functional and Structural Brain Recovery.
复制标题
白内障手术后的视力恢复促进大脑功能和结构恢复
DOI：
10.1016/j.ebiom.2018.03.002
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发表时间：
2018-04
期刊：
影响因子：
11.1
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Lin H;Zhang L;Lin D;Chen W;Zhu Y;Chen C;Chan KC;Liu Y;Chen W
Visual function and brain function decline concurrently with aging. Notably, cataract patients often present with accelerated age-related decreases in brain function, but the underlying mechanisms are still unclear. Optical structures of the anterior segment of the eyes, such as the lens and cornea, can be readily reconstructed to improve refraction and vision quality. However, the effects of visual restoration on human brain function and structure remain largely unexplored. A prospective, controlled clinical trial was conducted. Twenty-six patients with bilateral age-related cataracts (ARCs) who underwent phacoemulsification and intraocular lens implantation and 26 healthy controls without ARC, matched for age, sex, and education, were recruited. Visual functions (including visual acuity, visual evoke potential, and contrast sensitivity), the Mini-Mental State Examination and functional magnetic resonance imaging (including the fractional amplitude of low-frequency fluctuations and grey matter volume variation) were assessed for all the participants and reexamined for ARC patients after cataract surgery. This trial was registered with ClinicalTrials.gov (NCT02644720). Compared with the healthy controls, the ARC patients presented decreased brain functionality as well as structural alterations in visual and cognitive-related brain areas preoperatively. Three months postoperatively, significant functional improvements were observed in the visual and cognitive-related brain areas of the patients. Six months postoperatively, the patients' grey matter volumes in these areas were significantly increased. Notably, both the function and structure in the visual and cognitive-related brain areas of the patients improved significantly and became comparable to those of the healthy controls 6 months postoperatively. We demonstrated that ocular reconstruction can functionally and structurally reverse cataract-induced brain changes. The integrity of the eye is essential for maintaining the structure and function of the brain within and beyond the primary visual pathway. Cataract patients with reduced visual function presented a simultaneous decrease in brain function and grey matter volume. Cataract surgery can reverse cerebral changes in both visual and cognitive-related regions associated with visual decline. The integrity of the eye is essential for maintaining the structure and function of the brain. The eyes and brain are anatomically and functionally connected. Age related cataract (ARC) is associated with structural and functional impairments of the brain. However, whether these changes are reversible after cataract surgery is largely unknown. We assessed the patients based on subjective cognitive evaluations and objective functional magnetic resonance imaging before and after surgery. Significant improvements in brain function and increases in the grey matter volumes of the visual, cognitive-related, and somatosensory brain areas were observed, demonstrating that the impaired brain function and structure of ARC patients can be reversed after restoration of visual acuity.
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DOI：
10.12659/msm.904254
发表时间：
2017-09-22
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Li Y;Fang X;Zhao WG;Chen Y;Hu SL
通讯作者：
Hu SL
影响因子：
4.8
作者：
Abulafia C;Duarte-Abritta B;Villarreal MF;Ladrón-de-Guevara MS;García C;Sequeyra G;Sevlever G;Fiorentini L;Bär KJ;Gustafson DR;Vigo DE;Guinjoan SM
通讯作者：
Guinjoan SM
影响因子：
7
作者：
Dixon, Jasmine S.;Saddington, Deborah G.;Rosenberg, Paul B.
通讯作者：
Rosenberg, Paul B.
影响因子：
2.1
作者：
Liang, Peipeng;Xiang, Jie;Li, Kuncheng
通讯作者：
Li, Kuncheng
影响因子：
9.9
作者：
Cox, Simon R.;Dickie, David Alexander;Deary, Ian J.
通讯作者：
Deary, Ian J.