Animal Toxins Providing Insights into TRPV1 Activation Mechanism.
Animal Toxins Providing Insights into TRPV1 Activation Mechanism.
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DOI：
10.3390/toxins9100326
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发表时间：
2017-10-16
期刊：
影响因子：
4.2
通讯作者：
Priel A
中科院分区：
文献类型：
--
作者：
Geron M;Hazan A;Priel A
除了提供进化优势外，毒液还提供了独特的研究工具，因为它们被开发用于靶向功能重要的蛋白质和途径。瞬时受体电位香草酸1（TRPV1）是痛觉通路中的一个关键性疼痛受体，是多种毒素的作用靶点，可通过产生疼痛来阻止捕食者。重要的是，TRPV1参与体温调节、炎症和急性伤害感受。因此，毒素提供了了解TRPV1激活和调节的工具，这是推进疼痛研究和开发新型镇痛药的关键一步。事实上，辣椒中的辛辣化学物质辣椒素在TRPV1的原始克隆和表征中是非常宝贵的。每个随后表征的毒素的独特性质继续推进我们对TRPV1的功能，结构和生物物理特性的理解。通过建立在以前的评论，这项工作的目的是提供一个全面的总结TRPV1的研究进展，近年来采用动物毒素，特别是DkTx，RhTx，BmP01，Echis coloratus毒素，APHC和HCRG21。我们研究了每种毒素的功能方面，行为影响和结构特征，所有这些都有助于我们目前对TRPV1的了解。我们还讨论了TRPV1的外孔结构域的关键特征，这被证明是目前讨论的毒素的目标。
Beyond providing evolutionary advantages, venoms offer unique research tools, as they were developed to target functionally important proteins and pathways. As a key pain receptor in the nociceptive pathway, transient receptor potential vanilloid 1 (TRPV1) of the TRP superfamily has been shown to be a target for several toxins, as a way of producing pain to deter predators. Importantly, TRPV1 is involved in thermoregulation, inflammation, and acute nociception. As such, toxins provide tools to understand TRPV1 activation and modulation, a critical step in advancing pain research and the development of novel analgesics. Indeed, the phytotoxin capsaicin, which is the spicy chemical in chili peppers, was invaluable in the original cloning and characterization of TRPV1. The unique properties of each subsequently characterized toxin have continued to advance our understanding of functional, structural, and biophysical characteristics of TRPV1. By building on previous reviews, this work aims to provide a comprehensive summary of the advancements made in TRPV1 research in recent years by employing animal toxins, in particular DkTx, RhTx, BmP01, Echis coloratus toxins, APHCs and HCRG21. We examine each toxin’s functional aspects, behavioral effects, and structural features, all of which have contributed to our current knowledge of TRPV1. We additionally discuss the key features of TRPV1’s outer pore domain, which proves to be the target of the currently discussed toxins.
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影响因子：
16.2
作者：
Cao E;Cordero-Morales JF;Liu B;Qin F;Julius D
通讯作者：
Julius D
影响因子：
2.1
作者：
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通讯作者：
Rabago, David
影响因子：
5.4
作者：
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Grishin EV
影响因子：
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作者：
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通讯作者：
TRATSCHIN, JD
影响因子：
64.8
作者：
Bohlen, Christopher J.;Chesler, Alexander T.;Sharif-Naeini, Reza;Medzihradszky, Katalin F.;Zhou, Sharleen;King, David;Sanchez, Elda E.;Burlingame, Alma L.;Basbaum, Allan I.;Julius, David
通讯作者：
Julius, David