Higher non-HDL-cholesterol to HDL-cholesterol ratio linked with increased nonalcoholic steatohepatitis.
Higher non-HDL-cholesterol to HDL-cholesterol ratio linked with increased nonalcoholic steatohepatitis.
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较高的非 HDL 胆固醇与 HDL 胆固醇比率与非酒精性脂肪性肝炎增加相关
DOI：
10.1186/s12944-018-0720-x
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发表时间：
2018-04-03
影响因子：
4.5
通讯作者：
Jiang D
中科院分区：
文献类型：
--
作者：
Wang D;Wang L;Wang Z;Chen S;Ni Y;Jiang D
非HDL-胆固醇与HDL-胆固醇（非HDL-c/HDL-c）比值是冠心病、代谢综合征和胰岛素抵抗的可行预测因子。非酒精性脂肪性肝炎（NASH）患者发生心血管问题和2型糖尿病的风险增加。然而，非HDL-c/HDL-c比值在NASH中的预测作用尚未得到研究。我们进行了一项回顾性队列研究。本研究共选择了3489例合格受试者。阐明NASH的患病率和特点。采用条件Logistic回归分析非HDL-c/HDL-c比值与NASH风险的关系。还研究了非HDL-c/HDL-c比值与血清转氨酶水平之间的关系。NASH总患病率为6.13%，男性患病率（6.89%）高于女性患病率（5.04%）。有趣的是，NASH的患病率显示出与非HDL-c/HDL-c比率的升高正相关（Pearson卡方检验，线性趋势0.010，p < 0.05）。在非HDL-c/HDL-c比值较高的受试者中，NASH风险增加约1.8倍。调整混杂因素后，较高的非HDL-c/HDL-c比值仍与NASH风险增加54.4%相关。当非HDL-c/HDL-c比值升高时，男性患NASH的风险高于女性。BMI大于24的受试者发生NASH的风险是BMI小于24的受试者的3倍。校正混杂因素后，非HDL-c/HDL-c比值每增加一个单位，ALT/AST水平就增加64.5%（p < 0.05）。我们的研究提供了强有力的证据表明，非HDL-c/HDL-c比值较高的受试者发生NASH的风险较高，这表明非HDL-c/HDL-c比值可能是NASH的一个可行的预测因子。
Non-HDL-cholesterol to HDL-cholesterol (non-HDL-c/HDL-c) ratio is a feasible predictor for coronary heart disease, metabolic syndrome, and insulin resistance. Patients with nonalcoholic steatohepatitis (NASH) have an increased risk of developing cardiovascular problems and type 2 diabetes. However, the predictive role of non-HDL-c/HDL-c ratio in NASH hasn’t been investigated yet. We conducted a retrospective cohort study. A total of 3489 eligible subjects were selected in the present study. Prevalence and characteristics of NASH were demonstrated. Conditional logistic regression was used to analyze the association between non-HDL-c/HDL-c ratio and risks of NASH. Associations between non-HDL-c/HDL-c ratio and serum aminotransferase levels were also investigated. The overall prevalence of NASH was 6.13%, higher in male (6.89%) than that in female (5.04%). Interestingly, the prevalence of NASH showed a positive correlation with the elevation of non-HDL-c/HDL-c ratio (Pearson’s Chi-squared test, linear trend 0.010, p < 0.05). The risk of NASH increased approximately 1.8-fold among subjects with higher non-HDL-c/HDL-c ratio. After adjustment for confounding factors, higher non-HDL-c/HDL-c ratio was still associated with a 54.4% increased risk of NASH. Male had higher risk of NASH than female when their non-HDL-c/HDL-c ratio increased. The risk of NASH in subjects with BMI more than 24 was 3 times higher than that in subjects with BMI less than 24. Every one unit increase in Non-HDL-c/HDL-c ratio was associated with 64.5% increase in ALT/AST level (p < 0.05) after adjustment for confounding factors. Our study provided strong evidence that subjects with higher non-HDL-c/HDL-c ratio had a higher risk of NASH, which suggested that non-HDL-c/HDL-c ratio might be a feasible predictor for NASH.
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影响因子：
3.5
作者：
Kim, Se Won;Jee, Jae Hwan;Kim, Jae Hyeon
通讯作者：
Kim, Jae Hyeon
影响因子：
5.1
作者：
Carter, Danielle;Dieterich, Douglas T.;Chang, Charissa
通讯作者：
Chang, Charissa
影响因子：
50.3
作者：
Luedde, Tom;Beraza, Naiara;Pasparakis, Manolis
通讯作者：
Pasparakis, Manolis
DOI：
10.1038/oby.2005.147
发表时间：
2005-07-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Shen, YH;Yang, WS;Huang, KC
通讯作者：
Huang, KC
DOI：
10.1002/hep.27678
发表时间：
2015-04
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Sanyal AJ;Friedman SL;McCullough AJ;Dimick-Santos L;American Association for the Study of Liver Diseases;United States Food and Drug Administration
通讯作者：
United States Food and Drug Administration