Frontier Progress in the Establishment of Trophoblast Stem Cell and the Identification of New Cell Subtypes at the Maternal-Fetal Interface
Frontier Progress in the Establishment of Trophoblast Stem Cell and the Identification of New Cell Subtypes at the Maternal-Fetal Interface
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滋养层干细胞建立及母胎界面新细胞亚型鉴定的前沿进展
DOI：
10.1097/fm9.0000000000000023
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发表时间：
2019-10
影响因子：
1
通讯作者：
Hai-Bin Wang
中科院分区：
文献类型：
--
作者：
Xiao-bo Zhou;Chan Zhou;Yang Sun;Dong Liu;Shuang-Bo Kong;Jinhua Lu;Hongbo Qi;Hai-Bin Wang
人类胎盘的正常发育对妊娠的成功至关重要，一系列妊娠并发症被认为是由胎盘功能障碍引起的。像其他器官系统的发育一样，胎盘的形成需要大量的协同调节因子，而协调胎盘形成和功能的潜在分子机制却知之甚少。尽管我们在利用小鼠模型了解胎盘结构和发育方面取得了许多进展，但由于缺乏适当的模型系统，物种特异性差异阻碍了我们的进展。在过去的几年中，新的体外自我更新干细胞模型的建立以及母胎界面细胞组织的全貌已经取得了重大进展。为胎盘和生殖相关调控机制的研究提供工具。本文综述了人类滋养细胞干细胞培养系统的详细进展，以及母胎界面的细胞和分子地形，从而为胎盘发育提供新的见解。
Proper development of the human placenta is of vital importance for a successful pregnancy, and a series of pregnancy complications are considered originating from dysfunctional placentas. Like other organ system development, placentation requires large numbers of co-regulators, while the underlying molecular mechanisms orchestrating the placental formation and function are poorly understood. Although we have made many signs of progress in understanding the placental architectures and developments using mouse models, the species-specific differences impede our progress due to the lack of appropriate model systems. In the past few years, major progress has been made by the establishment of novel in-vitro self-renewing stem cell models, as well as identifying the full picture of the cellular organization of the maternal and fetal interface. Providing the tools for the investigation of placentation and reproductive-related regulation mechanism. In this review, we focus on the detailed progress of the human trophoblast stem cells culturing system, and the cellular and molecular terrain at the maternal-fetal interface, respectively, thus providing new insights into placental development.
Key words:
Human placenta; Maternal-fetal interface; Trophoblast stem cell
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DOI：
10.1146/annurev-pathmechdis-012418-012743
发表时间：
2019-01-24
期刊：
Annual review of pathology
影响因子：
--
作者：
Deshmukh H;Way SS
通讯作者：
Way SS
影响因子：
4.6
作者：
M. Wagner;M. Jöst;J. Spratte;M. Schaier;K. Mahnke;S. Meuer;M. Zeier;A. Steinborn
通讯作者：
M. Wagner;M. Jöst;J. Spratte;M. Schaier;K. Mahnke;S. Meuer;M. Zeier;A. Steinborn
影响因子：
3.8
作者：
Sonderegger, S.;Husslein, H.;Leisser, C.;Knoefler, A.
通讯作者：
Knoefler, A.
DOI：
10.1016/s0140-6736(05)17987-2
发表时间：
2005-03
期刊：
The Lancet
影响因子：
--
作者：
B. Sibai;G. Dekker;M. Kupferminc
通讯作者：
B. Sibai;G. Dekker;M. Kupferminc
亚麻 (Linum usitatissimum L.) 株高相关性状的共有遗传连锁图谱构建和 QTL 定位
影响因子：
5.3
作者：
Zhang J;Long Y;Wang L;Dang Z;Zhang T;Song X;Dang Z;Pei X
通讯作者：
Pei X