Associations of tumor suppressor SPARCL1 with cancer progression and prognosis.
Associations of tumor suppressor SPARCL1 with cancer progression and prognosis.
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DOI：
10.3892/ol.2017.6546
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发表时间：
2017-09
期刊：
影响因子：
2.9
通讯作者：
Zeng X
中科院分区：
文献类型：
--
作者：
Li T;Liu X;Yang A;Fu W;Yin F;Zeng X
SPARC-like protein 1（SPARCL 1）是一种富含半胱氨酸的酸性分泌蛋白家族成员，是多种肿瘤的潜在抑癌基因。本文对SPARCL 1与肿瘤进展及临床因素的关系进行了系统综述和生物信息学分析。SPARCL 1的下调被认为是通过包括DNA甲基化在内的表观遗传修饰来调节的，其在肿瘤的进展和发展中发挥重要作用，其调节细胞活力、迁移、侵袭、细胞粘附和耐药性。SPARCL 1的下调与≥7种实体瘤之一患者的总体生存率低显著相关，并预测≥4种不同肿瘤类型之一患者的死亡率增加。SPARCL 1有可能成为肿瘤治疗的靶点和判断预后的生物标志物。
SPARC-like protein 1 (SPARCL1), a member of the family of secreted proteins which is acidic and rich in cysteine, is a potential tumor suppressor gene in most types of tumor. A systemic review and bioinformatics analysis was carried out to determine the associations between SPARCL1 and tumor progression and clinical factors. Downregulation of SPARCL1, thought to be regulated by epigenetic modifications including DNA methylation, serves important functions in tumor progression and development, with its regulatory functions on cell viability, migration, invasion, cell adhesion and drug resistance. Downregulation of SPARCL1 was markedly associated with a poor overall survival rate of patients with one of ≥7 solid tumors and predicted increased mortality in patients with one of ≥4 distinct tumor types. The present review indicated that SPARCL1 may be a therapeutic target for cancer treatment and a biomarker to determine prognosis.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
6.4
作者：
Sato, Takashi;Arai, Eri;Kohno, Takashi;Takahashi, Yoriko;Miyata, Sayaka;Tsuta, Koji;Watanabe, Shun-ichi;Soejima, Kenzo;Betsuyaku, Tomoko;Kanai, Yae
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通讯作者：
Schaeffer EM
影响因子：
11.4
作者：
SCHRAML, P;SHIPMAN, R;LUDWIG, CU
通讯作者：
LUDWIG, CU
影响因子：
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作者：
Yu, Yang;Chen, Yan;Li, Zhaoshen
通讯作者：
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