Changes in nasal airflow and heat transfer correlate with symptom improvement after surgery for nasal obstruction.
Changes in nasal airflow and heat transfer correlate with symptom improvement after surgery for nasal obstruction.
复制标题
鼻气流和热传递的变化与鼻塞手术后症状的改善相关。
DOI：
10.1016/j.jbiomech.2013.08.007
复制
发表时间：
2013-10-18
影响因子：
2.4
通讯作者：
Rhee, J. S.
中科院分区：
文献类型：
--
作者：
Kimbell, J. S.;Frank, D. O.;Laud, Purushottam;Garcia, G. J. M.;Rhee, J. S.
纠正鼻气道阻塞 (NAO) 的手术通常效果不佳，部分原因是缺乏客观工具来为每位患者选择最合适的手术方法。计算流体动力学 (CFD) 模型可用于研究鼻气流，但需要确定可以检测手术变化并与患者症状相关的变量。 CFD 模型是根据 10 名 NAO 患者的术前和术后计算机断层扫描构建的，没有显示鼻循环的证据。计算双侧和单侧从鼻孔到后鼻中隔的主鼻腔的稳态吸气气流、鼻阻力、壁剪切应力和热通量。配对 t 检验表明，在阻塞最严重的一侧计算时，所有 CFD 变量均因手术而显着改变，并且双侧气流、鼻阻力和热通量也显着改变。当气流、热通量、气流的单侧分配以及单侧鼻阻力占双侧鼻阻力的一部分时，发现气流、热通量、单侧鼻阻力与患者报告的症状存在中等线性相关性，这表明这些变量可能有助于客观评估鼻手术的疗效。这些相关性强度的相似性表明，患者报告的症状可能代表一系列影响，并且在未来的虚拟手术计划期间应同时跟踪这些变量。
Surgeries to correct nasal airway obstruction (NAO) often have less than desirable outcomes, partly due to the absence of an objective tool to select the most appropriate surgical approach for each patient. Computational fluid dynamics (CFD) models can be used to investigate nasal airflow, but variables need to be identified that can detect surgical changes and correlate with patient symptoms. CFD models were constructed from pre- and post-surgery computed tomography scans for 10 NAO patients showing no evidence of nasal cycling. Steady-state inspiratory airflow, nasal resistance, wall shear stress, and heat flux were computed for the main nasal cavity from nostrils to posterior nasal septum both bilaterally and unilaterally. Paired t-tests indicated that all CFD variables were significantly changed by surgery when calculated on the most obstructed side, and that airflow, nasal resistance, and heat flux were significantly changed bilaterally as well. Moderate linear correlations with patient-reported symptoms were found for airflow, heat flux, unilateral allocation of airflow, and unilateral nasal resistance as a fraction of bilateral nasal resistance when calculated on the most obstructed nasal side, suggesting that these variables may be useful for evaluating the efficacy of nasal surgery objectively. Similarity in the strengths of these correlations suggests that patient-reported symptoms may represent a constellation of effects and that these variables should be tracked concurrently during future virtual surgery planning.
登录
查看更多内容
影响因子：
3.3
作者：
Kelly, JT;Prasad, AK;Wexler, AS
通讯作者：
Wexler, AS
DOI：
10.1089/jam.2006.0531
发表时间：
2007-03-01
期刊：
JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
影响因子：
--
作者：
Kimbell, Julia S.;Segal, Rebecca A.;Miller, Frederick J.
通讯作者：
Miller, Frederick J.
影响因子：
3.8
作者：
Naftali, S;Schroter, RC;Elad, D
通讯作者：
Elad, D
DOI：
10.1177/194589240602000220
发表时间：
2006-03-01
期刊：
AMERICAN JOURNAL OF RHINOLOGY
影响因子：
--
作者：
Lindemann, J;Keck, T;Pless, D
通讯作者：
Pless, D
影响因子：
3.3
作者：
HAHN, I;SCHERER, PW;MOZELL, MM
通讯作者：
MOZELL, MM