A proton beam therapy system dedicated to spot-scanning increases accuracy with moving tumors by real-time imaging and gating and reduces equipment size.
A proton beam therapy system dedicated to spot-scanning increases accuracy with moving tumors by real-time imaging and gating and reduces equipment size.
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DOI：
10.1371/journal.pone.0094971
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Shirato H
中科院分区：
文献类型：
--
作者：
Shimizu S;Miyamoto N;Matsuura T;Fujii Y;Umezawa M;Umegaki K;Hiramoto K;Shirato H
设计了一种质子束治疗（PBT）系统，该系统专用于点扫描，并具有门控功能，采用基于荧光透视的肿瘤附近内部基准标记的实时成像。在模拟实验中比较了新设计的实时图像门控点扫描质子束治疗（RGPT）与自由呼吸点扫描质子束治疗（FBPT）的剂量分布和治疗时间。内部模拟工具和治疗计划系统VQA（Hitachi，Ltd.，日本）用于估计剂量分布和治疗时间。对来自两名患者A和B的CT数据的48个运动参数（包括8种呼吸模式和6种初始呼吸定时）进行模拟，这两名患者患有肝细胞癌，临床靶体积分别为14.6 cc和63.1 cc。呼吸模式来自X射线实时肿瘤跟踪放射治疗（RTRT）中的内部基准标记的实际轨迹。使用FBPT，患者A和B分别有9/48和0/48的运动参数达到了成功分娩的标准。RGPT 48/48和42/48达到标准。与FBPT相比，RGPT的平均肝脏剂量较小，具有统计学显著性（p<0.001）;患者A和B的平均肝脏剂量分别从处方剂量的27%降至13%和28%降至23%。患者A和B给予3戈伊（RBE）的治疗时间相对延长估计分别为1.22（RGPT/FBPT：138 s/113 s）和1.72（207 s/120 s）。该模拟研究表明，RGPT能够显著改善移动肿瘤的剂量分布，而无需非常大的治疗时间延长。专用于点扫描的质子束治疗系统具有用于实时成像的门控功能，提高了移动肿瘤的准确性，并减小了物理尺寸，从而降低了设备以及容纳设备的建筑物的成本。
A proton beam therapy (PBT) system has been designed which dedicates to spot-scanning and has a gating function employing the fluoroscopy-based real-time-imaging of internal fiducial markers near tumors. The dose distribution and treatment time of the newly designed real-time-image gated, spot-scanning proton beam therapy (RGPT) were compared with free-breathing spot-scanning proton beam therapy (FBPT) in a simulation. In-house simulation tools and treatment planning system VQA (Hitachi, Ltd., Japan) were used for estimating the dose distribution and treatment time. Simulations were performed for 48 motion parameters (including 8 respiratory patterns and 6 initial breathing timings) on CT data from two patients, A and B, with hepatocellular carcinoma and with clinical target volumes 14.6 cc and 63.1 cc. The respiratory patterns were derived from the actual trajectory of internal fiducial markers taken in X-ray real-time tumor-tracking radiotherapy (RTRT). With FBPT, 9/48 motion parameters achieved the criteria of successful delivery for patient A and 0/48 for B. With RGPT 48/48 and 42/48 achieved the criteria. Compared with FBPT, the mean liver dose was smaller with RGPT with statistical significance (p<0.001); it decreased from 27% to 13% and 28% to 23% of the prescribed doses for patients A and B, respectively. The relative lengthening of treatment time to administer 3 Gy (RBE) was estimated to be 1.22 (RGPT/FBPT: 138 s/113 s) and 1.72 (207 s/120 s) for patients A and B, respectively. This simulation study demonstrated that the RGPT was able to improve the dose distribution markedly for moving tumors without very large treatment time extension. The proton beam therapy system dedicated to spot-scanning with a gating function for real-time imaging increases accuracy with moving tumors and reduces the physical size, and subsequently the cost of the equipment as well as of the building housing the equipment.
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DOI：
10.1186/1748-717x-8-48
发表时间：
2013-03-05
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Toramatsu C;Katoh N;Shimizu S;Nihongi H;Matsuura T;Takao S;Miyamoto N;Suzuki R;Sutherland K;Kinoshita R;Onimaru R;Ishikawa M;Umegaki K;Shirato H
通讯作者：
Shirato H
影响因子：
3.5
作者：
Tsunashima, Yoshikazu;Vedam, Sastry;Mohan, Radhe
通讯作者：
Mohan, Radhe
DOI：
10.1016/j.ijrobp.2005.11.016
发表时间：
2006-03-15
影响因子：
7
作者：
Shirato, H;Suzuki, K;Miyasaka, K
通讯作者：
Miyasaka, K
影响因子：
168.9
作者：
Shirato, H;Shimizu, S;Miyasaka, K
通讯作者：
Miyasaka, K
影响因子：
3.8
作者：
Matsuura, Taeko;Miyamoto, Naoki;Shirato, Hiroki
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Shirato, Hiroki