Psychosocial Syndemics are Additively Associated with Worse ART Adherence in HIV-Infected Individuals.
Psychosocial Syndemics are Additively Associated with Worse ART Adherence in HIV-Infected Individuals.
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DOI：
10.1007/s10461-014-0925-6
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发表时间：
2015-06
影响因子：
4.4
通讯作者：
Safren, Steven A.
中科院分区：
文献类型：
--
作者：
Blashill, Aaron J.;Bedoya, C. Andres;Mayer, Kenneth H.;O'Cleirigh, Conall;Pinkston, Megan M.;Remmert, Jocelyn E.;Mimiaga, Matthew J.;Safren, Steven A.
艾滋病毒感染者坚持抗逆转录病毒治疗（ART）对个人和公共健康都是必要的，心理社会问题与坚持性差独立相关。到目前为止，研究还没有系统地研究多重，共同发生的心理社会问题的影响（即，“syndemics”）对ART依从性的影响。参与者包括333名艾滋病毒感染者，他们完成了全面的基线评估，作为临床试验的一部分，以评估治疗抑郁症和优化药物依从性的干预措施。参与者完成了自我报告问卷，并培训过的临床医生完成了半结构化的诊断访谈。通过电子药丸帽（即，MEMS）。随着个体报告更多的综合征指标，他们不遵守的几率增加。同时发生的心理社会问题对ART依从性差的风险具有累加效应。未来的行为医学干预措施需要全面解决这些问题，和/或他们共享的核心机制。
Adherence to antiretroviral therapy (ART) among HIV-infected individuals is necessary to both individual and public health, and psychosocial problems have independently been associated with poor adherence. To date, studies have not systematically examined the effect of multiple, co-occurring psychosocial problems (i.e., “syndemics”) on ART adherence. Participants included 333 HIV-infected individuals who completed a comprehensive baseline evaluation, as part of a clinical trial to evaluate an intervention to treat depression and optimize medication adherence. Participants completed self-report questionnaires, and trained clinicians completed semi-structured diagnostic interviews. ART non-adherence was objectively measured via an electronic pill cap (i.e., MEMS). As individuals reported a greater number of syndemic indicators, their odds of non-adherence increased. Co-occurring psychosocial problems have an additive effect on the risk for poor ART adherence. Future behavioral medicine interventions are needed that address these problems comprehensively, and/or the core mechanisms that they share.
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影响因子：
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