Fitness, fatness, and coronary heart disease risk in adolescents: the Northern Ireland Young Hearts Project.
Fitness, fatness, and coronary heart disease risk in adolescents: the Northern Ireland Young Hearts Project.
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青少年的健康、肥胖和冠心病风险：北爱尔兰青年心脏项目。
DOI：
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发表时间：
2001
影响因子：
4.1
通讯作者：
G. Cran
中科院分区：
文献类型：
--
作者：
C. Boreham;J. Twisk;L. Murray;Maurice J Savage;J. Strain;G. Cran
目的
本研究的目的是检验 12 岁和 15 岁青少年冠心病 (CHD) 风险状态与身体脂肪和心肺 (C-R) 健康之间关联的独立性和相对强度。
方法
研究队列由 1015 名 12 岁和 15 岁的学童组成（251 名 12 岁男孩、258 名 12 岁女孩、252 名 15 岁男孩和 254 名 15 岁女孩），代表每个人口组的 2% 随机样本。在标准化条件下测定每个儿童的身高、体重、性成熟度（青春期状态）、皮褶厚度（4个部位）、血压（随机零血压计）、非空腹血清总量、高密度脂蛋白（HDL）胆固醇和C-R健康（20米往返跑；20-MST）。社会经济状况和习惯性身体活动也通过问卷信息确定。我们进行了多元回归分析，以检查五种冠心病风险因素与健康和肥胖之间的关系，并检查健康和肥胖对冠心病风险状态的相对强度，纠正潜在的混杂变量。
结果
我们的主要发现是：1）肥胖与冠心病危险因素之间的关系总是强于健康与相同危险因素之间的关系。例如，对 12 岁男孩进行部分调整的标准化回归系数显示，所有五个 CHD 风险因素与肥胖之间均存在显着关系，而五个因素中的三个则与健康相关。 12岁女孩的相应数字是五分之三（肥胖）和五分之一（健身）。对于 15 岁的人来说，结果大致相似。 2）尽管体能与冠心病风险因素之间的关系无法在对肥胖进行进一步调整后继续存在，但肥胖与冠心病风险之间的关系更为稳健，并且不受体能进一步调整的影响。
结论
我们的结果表明，观察到的青少年 C-R 健康与 CHD 风险状态之间的关系是由肥胖介导的，而观察到的与肥胖的关系与健康无关。因此，儿童期冠心病的一级预防应集中于预防或逆转体重过度增加。
PURPOSE
The purpose of this study was to examine the independence and relative strengths of association between coronary heart disease (CHD) risk status and both body fatness and cardiorespiratory (C-R) fitness in 12- and 15-yr-old adolescents.
METHODS
The study cohort consisted of 1015 schoolchildren aged 12 and 15 yr (251 12-yr-old boys, 258 12-yr-old girls, 252 15-yr-old boys, and 254 15-yr-old girls), representing a 2% random sample of each population group. For each child, height, weight, sexual maturity (pubertal status), skin-fold thicknesses (4 sites), blood pressure (random zero sphygmomanometer), nonfasting serum total, and high density lipoprotein (HDL)-cholesterol and C-R fitness (20-m shuttle run; 20-MST) were determined under standardized conditions. Socioeconomic status and habitual physical activity were also determined from questionnaire information. Multiple regression analyses were carried out to examine relationships between five CHD risk factors, and fitness and fatness and to examine the relative strengths of fitness and fatness on CHD risk status, correcting for potential confounding variables.
RESULTS
Our main findings were: 1) Relationships between fatness and CHD risk factors are invariably stronger than between fitness and the same risk factors. For example, partially adjusted standardized regression coefficients for 12-yr-old boys revealed significant relationships between all five CHD risk factors and fatness, compared with three of five for fitness. The corresponding figures for 12-yr-old girls were three of five (fatness) and one of five (fitness). Broadly similar results were apparent for 15-yr-olds. 2) Although relationships between fitness and CHD risk factors do not survive further adjustment for fatness, the relationships between fatness and CHD risk are more robust and are unaffected by further adjustment for fitness.
CONCLUSION
Our results indicate that the observed relationships between C-R fitness and CHD risk status in adolescents are mediated by fatness, whereas the observed relationships with fatness are independent of fitness. Primary prevention of CHD during childhood should therefore concentrate upon preventing or reversing undue weight gain.
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DOI：
10.1001/jama.1995.03520380029031
发表时间：
1995-04
期刊：
JAMA
影响因子：
--
作者：
S. Blair;H. Kohl;C. Barlow;R. Paffenbarger;L. Gibbons;C. Macera
通讯作者：
S. Blair;H. Kohl;C. Barlow;R. Paffenbarger;L. Gibbons;C. Macera
DOI：
--
发表时间：
1998
期刊：
The American journal of cardiology
影响因子：
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通讯作者：
H. Mcgill;C. Mcmahan
肥胖与儿童和年轻人心血管疾病危险因素聚集的关系。
影响因子：
5
作者：
Smoak,CG;Burke,GL;Webber,LS;Harsha,DW;Srinivasan,SR;Berenson,GS
通讯作者：
Berenson,GS
影响因子：
120.7
作者：
Luepker, RV;Perry, CL;Wu, M
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与体重无关的心血管健康和冠状动脉危险因素。
DOI：
10.1001/archpedi.1997.02170420032005
发表时间：
1997
影响因子：
--
作者：
Gutin,B;Owens,S;Treiber,F;Islam,S;Karp,W;Slavens,G
通讯作者：
Slavens,G