Manipulation of dopamine receptors alters hypoxic pulmonary vasoconstriction in isolated perfused rat lungs.
Manipulation of dopamine receptors alters hypoxic pulmonary vasoconstriction in isolated perfused rat lungs.
复制标题
多巴胺受体的操纵改变了离体灌注大鼠肺的缺氧肺血管收缩。
DOI：
10.1016/0024-3205(92)90630-8
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发表时间：
1992
期刊：
影响因子：
6.1
通讯作者：
W. Drummond
中科院分区：
文献类型：
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作者：
M. Polak;L. Kennedy;W. Drummond
采用大鼠肺灌流模型，观察缺氧性肺血管收缩反应(HPV)。我们研究了选择性DA1受体激动剂非诺多巴、选择性DA1拮抗剂SCH 23390及其合用对人乳头瘤病毒的影响。非诺多巴显著减弱HPV。SCH 23390对人乳头瘤病毒无影响，但可阻断非诺多巴的作用。这些数据证实了肺血管床中存在扩张血管的DA1受体。这些数据进一步表明，正在进行的DA1活性在平衡某些病理性肺动脉高压状态方面可能是重要的。
Using an isolated, perfused rat lung model, we examined the hypoxic pulmonary vasoconstriction (HPV). We studied the alterations in HPV induced by the selective DA1receptor agonist, fenoldopam, the selective DA1antagonist, SCH 23390, as well as a combination of these agents. Fenoldopam significantly attenuated HPV. SCH 23390 had no effect on HPV, but was ableto block the effect of fenoldopam. These data confirm the presence of vasodilatory DA1receptors in the pulmonary vascular bed. The data further suggest that ongoing DA1activity may be important in counterbalancing some pathologic pulmonary hypertensive states.
缺氧对离体羊肺白三烯活性和血管舒缩张力的影响。
DOI：
10.1152/jappl.1990.68.6.2457
发表时间：
1990
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Schnader,J;Undem,B;Adams3rd,GK;Peters,SP;Adkinson,NF;Sylvester,JT
通讯作者：
Sylvester,JT