Host species vary in infection probability, sub-lethal effects, and costs of immune response when exposed to an amphibian parasite.
Host species vary in infection probability, sub-lethal effects, and costs of immune response when exposed to an amphibian parasite.
复制标题
DOI：
10.1038/srep10828
复制
发表时间：
2015-05-29
影响因子：
4.6
通讯作者：
Garner TW
中科院分区：
文献类型：
--
作者：
Bielby J;Fisher MC;Clare FC;Rosa GM;Garner TW
两栖类寄生虫Batrachochytrium dendrobaestrium（Bd）被认为是一个极端的多面手，感染超过500种，但在这些主机之间存在着很大的变化的易感性和寄生虫暴露的成本。我们使用两个感染实验，以确定是否种间变异的寄生虫暴露的亚致死和致死的影响存在于两个宿主物种。然后，我们测试了相对作用的主机密度和多样性的感染概率的焦点易感主机。我们的研究结果表明，宿主物种对寄生虫暴露的反应具有显着的异质性，并且在能够抵抗感染的个体中存在致死和亚致死成本，这表明成功的感染免疫反应是有代价的。此外，我们表明，无论宿主多样性和宿主易感性的变化如何，增加宿主密度都会显着增加易感个体感染Bd的可能性。这些结果表明，耐药物种的人口很可能遭受不良影响的暴露于Bd，无论其感染状态，并在初始感染的阶段，有没有支持稀释的传输事件，在其他研究中，重点是随后的感染传播。
The amphibian parasite Batrachochytrium dendrobatidis (Bd) is regarded as an extreme generalist, infecting over 500 species, but amongst these hosts there exists a great deal of variation in the susceptibility to and the costs of parasite exposure. We use two infection experiments to determine whether inter-specific variation in the sublethal and lethal effects of parasite exposure exist in two host species. We then tested the relative roles of host density and diversity on infection probability of a focal susceptible host. Our results show significant heterogeneity in host species response to parasite exposure, and that both lethal and sub-lethal costs exist in individuals that are able to resist infection, indicating that successful immune response to infection comes at a cost. Further, we show that increasing host density significantly increased the likelihood of susceptible individuals becoming infected with Bd irrespective of host diversity and variation in host susceptibility. These results suggest that populations of resistant species are likely to suffer ill-effects of exposure to Bd regardless of their infection status, and that at the stage of initial infection there was no support for the dilution of transmission events, in contrast to other studies that focus on subsequent transmission of infection.
登录
查看更多内容
影响因子：
11.8
作者：
Fenton A;Pedersen AB
通讯作者：
Pedersen AB
影响因子：
8.8
作者：
Holt, RD;Dobson, AP;Schauber, EM
通讯作者：
Schauber, EM
影响因子：
11.6
作者：
Garner, Trenton W. J.;Rowcliffe, J. Marcus;Fisher, Matthew C.
通讯作者：
Fisher, Matthew C.
DOI：
10.1073/pnas.0506889103
发表时间：
2006-02-28
影响因子：
11.1
作者：
Lips, KR;Brem, F;Collins, JP
通讯作者：
Collins, JP
影响因子：
10.7
作者：
Duda, TF;Vanhoye, D;Nicolas, P
通讯作者：
Nicolas, P