Lipoprotein Heterogeneity Early in Pregnancy and Preterm Birth.
Lipoprotein Heterogeneity Early in Pregnancy and Preterm Birth.
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DOI：
10.1055/s-0037-1603471
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发表时间：
2017-11
影响因子：
2
通讯作者：
Simhan HN
中科院分区：
文献类型：
--
作者：
Catov JM;Mackey RH;Scifres CM;Bertolet M;Simhan HN
脂蛋白颗粒的浓度和大小与种族、炎症和疾病有关。当甘油三酯高时，如在怀孕期间，脂蛋白颗粒大小可能具有超出常规脂质测量的生理重要性。我们认为脂蛋白颗粒可能与早产有关，并探讨了种族差异。在妊娠9周时采集样本（22例PTB [<37周]; 42例足月分娩[≥37周]）。使用标准技术测定脂质。使用NMR光谱定量高密度脂蛋白、低密度脂蛋白、极低密度脂蛋白颗粒（HDL-P、LDL-P和VLDL-P）和全身炎症标志物的浓度，并与PTB相关。与足月分娩的女性相比，PTB女性的VLDL-P较低（−10.66 nmol/L，p=0.03）和全身炎症较高（+19.2 μmol/L，p=0.02），与种族、孕前BMI和吸烟无关。黑人与白色女性相比，VLDL-P较低，HDL-胆固醇较高（均p<0.05）。种族特异性结果表明，仅在黑人女性中，PTB的高HDL-P和炎症（GlycB）高于足月分娩。PTB妇女在妊娠早期VLDL-P较低，这可能代表脂质反应受损。脂蛋白谱的黑白差异与非妊娠成年人相似，但种族特异性脂蛋白和炎症与PTB的相关性值得进一步研究。
The concentration and size of lipoprotein particles are associated with race, inflammation and disease. When triglycerides are high, as in pregnancy, lipoprotein particle size may have physiologic importance beyond conventional lipid measurements. We considered that lipoprotein particles may be related to preterm birth (PTB), and explored race differences. Samples were collected at 9 weeks gestation (22 PTB [<37 weeks]; 42 term births [≥37 weeks]). Lipids were assayed using standard techniques. Concentrations of high-density lipoprotein, low-density lipoprotein, very low-density lipoprotein particles (HDL-P, LDL-P, and VLDL-P) and markers of systemic inflammation were quantified using NMR spectroscopy and related to PTB. Women with PTB had lower VLDL-P (−10.66 nmol/L, p=0.03) and higher systemic inflammation (+19.2 μmol/L, p=0.02) compared to women with term births, independent of race, pre-pregnancy BMI and smoking. Black vs. White women had lower VLDL-P and higher HDL-cholesterol (both p<0.05). Race-specific results indicated that large HDL-P and inflammation (GlycB) were higher with PTB vs. term birth among black women only. Women with PTB had lower VLDL-P early in pregnancy, which may represent impaired lipid response. Black-White differences in the lipoprotein profile are similar to non-pregnant adults, but race-specific lipoprotein and inflammation associations with PTB warrant further study.
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DOI：
10.1016/j.amjcard.2015.01.015
发表时间：
2015-04-01
期刊：
The American journal of cardiology
影响因子：
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作者：
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DOI：
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2012-06
影响因子：
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发表时间：
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期刊：
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影响因子：
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作者：
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影响因子：
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