Potassium Channels in the Uterine Vasculature: Role in Healthy and Complicated Pregnancies.
Potassium Channels in the Uterine Vasculature: Role in Healthy and Complicated Pregnancies.
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子宫脉管系统中的钾通道：在健康和复杂的妊娠中的作用。
DOI：
10.3390/ijms23169446
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发表时间：
2022-08-21
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
在怀孕期间，母体子宫和胎盘血流必须逐渐增加，以维持胎儿的发育。母体血管系统的变化能够增加子宫血流、胎盘营养和氧气交换以及随后的胎儿发育。K+通道是血管功能的重要调节剂，促进血管舒张，诱导细胞增殖和调节细胞信号传导。不同类型的K+通道，如Ca2+激活的、ATP敏感的和电压门控的，已经涉及妊娠期间母体血管系统的适应。相反，K+通道功能障碍与血管相关的妊娠并发症有关，包括宫内生长受限和先兆子痫。在这篇文章中，我们提供了一个最新的和全面的文献综述，强调了相关的K+通道作为子宫血管反应性的调节剂和其作为治疗靶点的潜力。
A progressive increase in maternal uterine and placental blood flow must occur during pregnancy to sustain the development of the fetus. Changes in maternal vasculature enable an increased uterine blood flow, placental nutrient and oxygen exchange, and subsequent fetal development. K+ channels are important modulators of vascular function, promoting vasodilation, inducing cell proliferation, and regulating cell signaling. Different types of K+ channels, such as Ca2+-activated, ATP-sensitive, and voltage-gated, have been implicated in the adaptation of maternal vasculature during pregnancy. Conversely, K+ channel dysfunction has been associated with vascular-related complications of pregnancy, including intrauterine growth restriction and pre-eclampsia. In this article, we provide an updated and comprehensive literature review that highlights the relevance of K+ channels as regulators of uterine vascular reactivity and their potential as therapeutic targets.
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DOI：
10.1161/hypertensionaha.115.05299
发表时间：
2015-07
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Chen M;Xiao D;Hu XQ;Dasgupta C;Yang S;Zhang L
通讯作者：
Zhang L
影响因子：
20.1
作者：
Cole, WC;Malcolm, T;Light, PE
通讯作者：
Light, PE
影响因子：
5.5
作者：
Behringer, Erik J.;Segal, Steven S.
通讯作者：
Segal, Steven S.
影响因子：
9.8
作者：
Dong, Yuan-Lin;Chauhan, Madhu;Yallampalli, Chandra
通讯作者：
Yallampalli, Chandra
影响因子：
8.3
作者：
Aziz, Qadeer;Thomas, Alison M.;Tinker, Andrew
通讯作者：
Tinker, Andrew