Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies.
Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies.
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DOI：
10.1186/1471-2431-13-121
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发表时间：
2013-08-13
期刊：
影响因子：
2.4
通讯作者：
Bracken MB
中科院分区：
文献类型：
--
作者：
Egan KB;Ettinger AS;Bracken MB
近年来，儿童哮喘和肥胖症的患病率有所上升，这表明两者之间存在潜在的联系。然而，人们对任何关联的方向都知之甚少，潜在的因果关系也是未知的。我们调查了超重/肥胖(由18岁的身体质量指数(BMI)定义)与BMI评估后至少一年后医生诊断的哮喘事件之间的关系。我们试图探索通过性别改变的潜在影响。PubMed和Embase使用关键词进行搜索，仅限于0-18岁的受试者。没有日期或语言限制。我们从每项研究中提取：作者、发表日期、地点、超重/肥胖定义、哮喘定义、参与者数量、招募持续时间、队列描述、随访时间、调整后的效果估计(95%可信区间)和亚组分析估计。6项以18岁以下儿童为研究对象的前瞻性队列研究符合纳入标准。超重的综合危险比(RR = )为1.35，95%CI = 为1.15，1.58。在男孩中，超重对哮喘的综合RR显著(RR = 1.41；95%CI = 1.05，1.88)。对于女孩，当以Z-Score定义体重指数时，超重对哮喘的综合RR也是显著的(RR = 1.19；95%CI = 1.06，1.34)。肥胖的综合危险比(RR)在男女生(RR = 1.5 0；95%CI = 1.2 2，1.83)、男童(RR = 1.4 0；95%CI = 1.0 1，1.93)和女童(RR = 1.5 3；95%CI = 1.0 9，2.14)中均与哮喘有关。与正常体重的儿童相比，超重，特别是肥胖的儿童随后被医生诊断为哮喘的风险更高。除了性行为，没有研究报告有任何其他潜在的效果修饰物。观察到的性影响是不一致的。
Childhood asthma and obesity prevalence have increased in recent years suggesting a potential association. However, the direction of any association is poorly understood and the potential causal-relationship is unknown. We examined the association between overweight/obesity, defined by body mass index (BMI) <18 years of age, and subsequent physician-diagnosed incident asthma at least one year after BMI assessment. We sought to explore potential effect modification by sex. PubMed and Embase were searched using keywords and restricted to subjects aged 0–18 years. There were no date or language restrictions. From each study we extracted: authors, publication date, location, overweight/obesity definitions, asthma definitions, number of participants, recruitment duration, description of cohort, follow-up time, adjusted effect estimates (with 95% CI) and estimates of subgroup analysis. Six prospective cohort studies which focused on children <18 years of age met criteria for inclusion. The combined risk ratio (RR) of overweight was associated with asthma (RR = 1.35; 95% CI = 1.15, 1.58). In boys, the combined RR of overweight on asthma was significant (RR = 1.41; 95% CI = 1.05, 1.88). For girls, when BMI was defined by Z-score, the combined RR of overweight on asthma was also significant (RR = 1.19; 95% CI = 1.06, 1.34). The combined risk ratio (RR) of obesity was associated with asthma in both boys and girls (RR = 1.50; 95% CI = 1.22, 1.83), in boys only (RR = 1.40; 95% CI = 1.01, 1.93) and in girls only (RR = 1.53; 95% CI = 1.09, 2.14). Overweight and, especially, obese children are at increased risk of subsequent physician diagnosed asthma in comparison to normal weight children. Except for sex, no studies reported any other potential effect modifiers. The observed sex effects were inconsistent.
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DOI：
10.1016/j.jaci.2011.03.036
发表时间：
2011-06
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Holguin F;Bleecker ER;Busse WW;Calhoun WJ;Castro M;Erzurum SC;Fitzpatrick AM;Gaston B;Israel E;Jarjour NN;Moore WC;Peters SP;Yonas M;Teague WG;Wenzel SE
通讯作者：
Wenzel SE
影响因子：
8
作者：
Barlow, Sarah E.
通讯作者：
Barlow, Sarah E.
影响因子：
8
作者：
Akinbami, Lara J.;Moorman, Jeanne E.;Sondik, Edward J.
通讯作者：
Sondik, Edward J.
影响因子：
7.6
作者：
Brener, ND;McManus, T;Wechsler, H
通讯作者：
Wechsler, H
DOI：
10.1164/ajrccm.164.11.2004235
发表时间：
2001-12-01
影响因子：
24.7
作者：
Beckett, WS;Jacobs, DR;Williams, D
通讯作者：
Williams, D