Intolerable secretion in tolerant transgenic mice
Intolerable secretion in tolerant transgenic mice
复制标题
耐受转基因小鼠的不可耐受分泌
作者：
P. Parham
预计，在组织特异性启动子的控制下，克隆基因片段在转基因小鼠中的表达将有助于剖析和最终阐明构成自身免疫性疾病的环境和基因组之间复杂的相互作用。这句话来自我酝酿中的拨款申请，提出了希望，也就是政党路线。事实上，转基因小鼠是免疫学的神秘之旅；它们是新的、令人兴奋的，没有人知道它们会去哪里。Allison等人的论文生动地说明了这一点。在本期第529页上。这些作者开始建立一个简单的糖尿病小鼠模型，由胰腺细胞的免疫破坏引起。相反，他们提出了一种新的疾病形式，结果-
“IT Is anticipated that the expression in transgenic mice of cloned gene segments, under control of tissue-specific promo-ters, will facilitate dissection and eventual elucidation of the elaborate interplay between environment and genome that constitutes autoimmune disease”. This Opening sentence from my gestating grant application propounds the hopes, the party line. In reality, transgenic mice are the mystery tour of immunology; they are new and exciting and no one knows where they will go. This is vividly illustrated by the paper of Allison et al. on page 529 of this issue". These authors set out to esta-blish a simple mouse model for diabetes, caused by immune destruction of pancreatic (-cells. Instead they have come up with a new form of the disease, result-
DOI：
10.1056/nejm198605223142106
发表时间：
1986-05
期刊：
The New England Journal of Medicine
影响因子：
--
作者：
G. Eisenbarth
通讯作者：
G. Eisenbarth