Diabetes is associated with a lower minimum moment of inertia among older women: An analysis of 3D reconstructions of clinical CT scans.
Diabetes is associated with a lower minimum moment of inertia among older women: An analysis of 3D reconstructions of clinical CT scans.
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老年女性中糖尿病与较低的最小转动惯量有关：临床CT扫描的3D重建分析。
DOI：
10.1016/j.jbiomech.2021.110707
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发表时间：
2021-11-09
影响因子：
2.4
通讯作者：
Lee, Richard H.
中科院分区：
文献类型：
--
作者：
Heckelman, Lauren N.;Wesorick, Benjamin R.;DeFrate, Louis E.;Lee, Richard H.
髋部骨折是老龄化人口的沉重负担，通常导致活动能力降低，丧失独立性，甚至死亡。虽然骨折风险通常与骨矿物质密度（BMD）呈负相关，但糖尿病患者尽管具有较高的BMD，但骨折率较高。为了更好地了解糖尿病和骨折风险之间的联系，我们开发了一种方法来测量骨盆临床CT扫描的最小惯性矩（mMOI;与骨折风险相关的几何因子）。由于髋部骨折最常见于沿着股骨颈和成年女性，我们假设患有糖尿病的女性沿股骨颈的mMOI沿着比没有糖尿病的女性低，表明骨折风险较高。每个髋关节的三维模型是根据40名老年妇女的临床CT扫描创建的（27名糖尿病患者：10名骨折/17名非骨折; 13名无糖尿病患者：非骨折对照）。每例髋关节（n=80）的mMOI报告为3次试验的平均值。在调整年龄和BMI后，糖尿病患者的mMOI比非糖尿病患者低18%（p=0.02）。糖尿病患者骨折髋关节（3.4±1.2 cm 4）与对侧非骨折髋关节（3.4±0.9 cm 4; p=0.78）或糖尿病患者非骨折髋关节（2.8±0.7 cm 4; p=0.12）之间的mMOI无差异。这表明患有和不患有糖尿病的个体的髋部结构差异（通过mMOI测量）可能与糖尿病成人中骨折率升高有关。
Hip fractures are a heavy burden on the aging population, often resulting in reduced mobility, loss of independence, and even death. While fracture risk is generally inversely related to bone mineral density (BMD), people with diabetes suffer a higher fracture rate despite having a higher BMD. To better understand the connection between diabetes and fracture risk, we developed a method to measure the minimum moment of inertia (mMOI; a geometric factor associated with fracture risk) from clinical CT scans of the pelvis. Since hip fractures are most prevalent along the femoral neck and in female adults, we hypothesized that females with diabetes would have a lower mMOI along the femoral neck than those without diabetes, indicative of a higher fracture risk. Three-dimensional models of each hip were created from clinical CT scans of 40 older women (27 with diabetes: 10 fracture/17 non-fractured; 13 without diabetes: non-fractured controls). The mMOI of each hip (n=80) was reported as the average from three trials. People with diabetes had an 18% lower mMOI as compared to those without diabetes after adjusting for age and BMI (p=0.02). No differences in the mMOIs between the fractured hips of people with diabetes (3.4±1.2 cm4) and the contralateral non-fractured hips (3.4±0.9 cm4; p=0.78) or those of the non-fractured hips of people with diabetes (2.8±0.7 cm4; p=0.12) were observed. This suggests structural differences in the hips of individuals with and without diabetes (measured by the mMOI) may be associated with the elevated fracture rate among adults with diabetes.
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影响因子：
6.6
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Fajar JK;Taufan T;Syarif M;Azharuddin A
通讯作者：
Azharuddin A
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